Iwasaki H, Enjoji M
Acta Pathol Jpn. 1979 May;29(3):377-88. doi: 10.1111/j.1440-1827.1979.tb00195.x.
Histologic sections of 68 soft-tissue sarcomas initially diagnosed as fibrosarcoma were reviewed, and 36 were excluded because of revised diagnosis. The tumors from the remaining 32 patients were analyzed clinicopathologically, and were classifed into two types; the adult type (22 cases) and the infantile type (10 cases). The adult type fibrosarcoma occurred in adults aged 25 to 67 years and consisted of spindle-shaped fibroblastic cells which formed interlacing bundles accompanied by variable amounts of collagen or reticulin fibers. The infantile fibrosarcoma affected children below the age of seven years in this series and was characterized by proliferation of immature fibroblasts forming indistinct bundles, frequently exhibiting areas of an angiosarcoma-like pattern and cavernous blood vessels. The authors expressed the view that infantile fibrosarcoma should be separated from adult fibrosarcoma, because between these two types of fibrosarcoma there were marked differences in the histologic feature as well as in the age, sex and anatomical distributions.
对最初诊断为纤维肉瘤的68例软组织肉瘤的组织学切片进行了复查，其中36例因诊断修正而被排除。对其余32例患者的肿瘤进行了临床病理分析，并分为两型：成人型（22例）和婴儿型（10例）。成人型纤维肉瘤发生于25至67岁的成年人，由梭形的成纤维细胞组成，这些细胞形成交错的束状结构，并伴有不同数量的胶原纤维或网状纤维。在本系列中，婴儿型纤维肉瘤累及7岁以下儿童，其特征为未成熟的成纤维细胞增生，形成不明显的束状结构，常表现出类似血管肉瘤的区域和海绵状血管。作者认为婴儿型纤维肉瘤应与成人型纤维肉瘤区分开来，因为这两种类型的纤维肉瘤在组织学特征以及年龄、性别和解剖分布方面存在明显差异。
