Kline R L
Am Heart J. 1979 Jul;98(1):39-44. doi: 10.1016/0002-8703(79)90318-1.
Left circumflex coronary blood flow was increased significantly (20 per cent) during stimulation of somatic afferent fibers. The change in CBF was associated with significant increases in heart rate and arterial pressure and significant decrease in coronary vascular resistance. Controlling heart rate or preventing cardiac beta-adrenergic effects with propranolol during somatic nerve stimulation resulted in increases in CBF and arterial pressure with no change in coronary resistance. These results indicate that stimulation of a somatic nerve elicited an increase in CBF which could be explained on the basis of an increase in perfusion pressure plus a decrease in CVR resulting from the increased metabolic demand secondary to the increase in heart rate. There was no evidence of a significant neural component directly affecting CVR, even in the presence of beta-adrenergic blockade.
刺激躯体传入纤维时，左旋冠状动脉血流量显著增加（20%）。冠状动脉血流量的变化与心率和动脉压的显著升高以及冠状动脉血管阻力的显著降低有关。在躯体神经刺激期间，用普萘洛尔控制心率或防止心脏β-肾上腺素能效应，会导致冠状动脉血流量和动脉压升高，而冠状动脉阻力无变化。这些结果表明，刺激躯体神经会引起冠状动脉血流量增加，这可以基于灌注压的升高以及由于心率增加继发代谢需求增加导致的冠状动脉血管阻力降低来解释。即使存在β-肾上腺素能阻滞剂，也没有证据表明存在直接影响冠状动脉血管阻力的显著神经成分。
