James L P, Stass S A, Peterson V, Schumacher H R
Am J Clin Pathol. 1979 May;71(5):600-2. doi: 10.1093/ajcp/71.5.600.
In the proper clinical setting, phagocytosis by bone marrow histiocytes of erythrocytes, granulocytes, and platelets (panphagocytosis) is generally accepted as the morphologic hallmark of histiocytic medullary reticulosis. A patient with clinical manifestations that suggested histiocytic medullary reticulosis was found also to have histiocytic panphagocytosis in the bone marrow. Biopsy of the liver, however, revealed metastatic adenocarcinoma. In addition, postmortem examination demonstrated a gastric adenocarcinoma with massive hepatic involvement and absence of lymphadenopathy, splenomegaly, or evidence of generalized histiocytic proliferation. Therefore, histiocytic panphagocytosis is probably not specific for histiocytic medullary reticulosis, and may be a nonspecific feature of a variety of diseases.
在适当的临床环境中，骨髓组织细胞对红细胞、粒细胞和血小板的吞噬作用（全吞噬）通常被认为是组织细胞性髓性网状细胞增生症的形态学标志。一名有临床表现提示组织细胞性髓性网状细胞增生症的患者，骨髓中也发现有组织细胞全吞噬现象。然而，肝脏活检显示为转移性腺癌。此外，尸检发现有胃腺癌伴肝脏广泛受累，且无淋巴结病、脾肿大或全身性组织细胞增生的证据。因此，组织细胞全吞噬可能并非组织细胞性髓性网状细胞增生症所特有，可能是多种疾病的非特异性特征。
