Antagonistic properties of N-methyl-N'-[2-(5-ethyl-4-imidazolyl-methylthio)ethyl]thiourea.

In the present paper the Authors describe the synthesis and the biological effects of N-methyl-N'-[2-(5-ethyl-4-imidazolylmethylthio)ethyl]thiourea (etiamide). This compound appeared to inhibit, to a certain extent, the effect of histamine on H2-receptors. This inhibition, however, was less pronounced than that elicited by metiamide and in some of the preparations examined appeared to be of the non-competitive type.