Lopez-Majano V, Lin S C, Lee J K
Scand J Respir Dis Suppl. 1974;85:169-74.
Regional lung function studies were obtained with a gamma camera. The ventilation was studied with 133Xe and radioactive particles and the pulmonary circulation with radioactive particles and the pulmonary circulation with radioactive particles. Some pathophysiologic patterns could be defined with this methodology, i.e. in chronic uncomplicated pulmonary embolism the pathophysologic pattern was normal ventilation with decreased or absent perfusion in the affected areas, when C.O.L.D. was associated with pulmonary embolism the ventilation with 133Xenon could be normal if the C.O.L.D. was mild but the inhaled particles deposited in foci. In bullous disease the inhaled 133Xenon reached the blebs with delay and that wash-out was prolonged, the particles did not reach the blebs, the perfusion was absent in the areas with blebs. Similar pattern was present in bronchial obstruction. In hilar masses the defect in perfusion and ventilation was usually larger than the one expected from the lesion.
使用γ相机进行区域肺功能研究。用133氙和放射性颗粒研究通气情况，用放射性颗粒研究肺循环情况。通过这种方法可以确定一些病理生理模式，即：在慢性单纯性肺栓塞中，病理生理模式为患区通气正常但灌注减少或缺失；当慢性阻塞性肺疾病（C.O.L.D.）与肺栓塞相关时，如果C.O.L.D.较轻，133氙通气可能正常，但吸入颗粒沉积在病灶处。在大疱性疾病中，吸入的133氙延迟到达肺大疱且洗脱延长，颗粒未到达肺大疱，肺大疱区域无灌注。支气管阻塞中也存在类似模式。在肺门肿块中，灌注和通气缺陷通常比根据病变预期的更大。
