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乙醚对大鼠胰腺分离组织中葡萄糖刺激的胰岛素分泌的抑制作用。

Inhibition by ether of glucose-stimulated insulin secretion in isolated pieces of rat pancreas.

作者信息

Gingerich R L, Paradise R R, Wright P H

出版信息

Anesthesiology. 1979 Jul;51(1):34-5. doi: 10.1097/00000542-197907000-00007.

DOI:10.1097/00000542-197907000-00007
PMID:453590
Abstract

Addition of glucose (16.7 mM) to isolated pieces of rat pancreas increased insulin secretion 5.4-fold over basal secretion rates. Ether at 1, 1.5 and 2 MAC inhibited this insulinogenic effect of glucose in a dose-related manner by 5, 18 (P less than 0.01) and 29 (P less than 0.01) per cent, respectively.

摘要

向分离的大鼠胰腺组织块中添加葡萄糖(16.7 mM),可使胰岛素分泌量比基础分泌率增加5.4倍。1、1.5和2倍最低肺泡有效浓度(MAC)的乙醚分别以剂量相关的方式抑制葡萄糖的这种促胰岛素分泌作用,抑制率分别为5%、18%(P<0.01)和29%(P<0.01)。

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