Snow R M, Miller W C, Blair H T, Rice D L
Ann Allergy. 1979 May;42(5):286-9.
Ten adult asthmatics inhaled atropine and isoproterenol to determine the site of action in the airways and relative effectiveness of the two drugs. The two agents were equal in their effect on lung volumes and airway resistance but isoproterenol produced significantly better flows. Atropine was shown to be an effective bronchodilator with a predominant site of action in large airways. The authors believe atropine and atropine derivatives deserve ongoing investigation, especially regarding potential side effects of retarding mucociliary clearance and the clinical significance of apparent failure to dilate small airways.
十名成年哮喘患者吸入阿托品和异丙肾上腺素，以确定这两种药物在气道中的作用部位和相对疗效。这两种药物对肺容量和气道阻力的作用相同，但异丙肾上腺素产生的气流明显更好。阿托品被证明是一种有效的支气管扩张剂，主要作用部位在大气道。作者认为，阿托品及其衍生物值得持续研究，特别是关于其延缓黏液纤毛清除的潜在副作用以及未能有效扩张小气道的临床意义。
