关于多巴脱羧酶和5-羟色氨酸脱羧酶的同一性（免疫滴定 - 芳香族L-氨基酸脱羧酶 - 血清素 - 多巴胺 - 去甲肾上腺素）
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
作者信息
Christenson J G, Dairman W, Udenfriend S
出版信息
Proc Natl Acad Sci U S A. 1972 Feb;69(2):343-7. doi: 10.1073/pnas.69.2.343.
Abstract
Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.
摘要
对来自多种物种的多个组织中的多巴和5-羟色氨酸脱羧酶活性进行同步免疫滴定，结果表明，用针对猪肾脱羧酶的单特异性抗血清无法区分这两种活性。结合先前的研究结果，这些数据有力地证实了以下概念：在哺乳动物组织中，这两种酶活性与单一蛋白质相关，即芳香族L-氨基酸脱羧酶。
相似文献
1
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).关于多巴脱羧酶和5-羟色氨酸脱羧酶的同一性（免疫滴定 - 芳香族L-氨基酸脱羧酶 - 血清素 - 多巴胺 - 去甲肾上腺素）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):343-7. doi: 10.1073/pnas.69.2.343.
2
Ambivalence on the multiplicity of mammalian aromatic L-amino acid decarboxylase.对哺乳动物芳香族L-氨基酸脱羧酶多样性的矛盾态度。
Adv Exp Med Biol. 1991;294:115-25. doi: 10.1007/978-1-4684-5952-4_10.
3
Biochemical characteristics of mammalian brain 5-hydroxytryptophan decarboxylase activity.哺乳动物脑5-羟色氨酸脱羧酶活性的生化特性
Adv Biochem Psychopharmacol. 1974;11(0):43-50.
4
Rat brain L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities: differential effect of 6-hydroxydopamine.大鼠脑L-3,4-二羟基苯丙氨酸和L-5-羟色氨酸脱羧酶活性：6-羟基多巴胺的不同作用
Brain Res. 1973 Jan 15;49(1):165-75. doi: 10.1016/0006-8993(73)90408-3.
5
Role of catechol structure in the inhibitory effects of D-isomers of amino acids on the decarboxylation of L-5-hydroxytryptophan.儿茶酚结构在氨基酸D-异构体对L-5-羟色氨酸脱羧作用的抑制效应中的作用。
Experientia. 1978 Sep 15;34(9):1188-9. doi: 10.1007/BF01922950.
6
Characteristics of enzymic decarboxylation of L-threo-3,4-dihydroxyphenylserine using hog renal L-aromatic amino acid decarboxylase.使用猪肾L-芳香族氨基酸脱羧酶对L-苏式-3,4-二羟基苯丝氨酸进行酶促脱羧反应的特性。
Biochem Pharmacol. 1978 Apr 1;27(7):1081-6. doi: 10.1016/0006-2952(78)90161-2.
7
A possible feed-back mechanism controlling the biosynthesis of 5-hydroxytryptamine.一种可能控制5-羟色胺生物合成的反馈机制。
Biochem Pharmacol. 1967 Oct;16(10):1981-7. doi: 10.1016/0006-2952(67)90309-7.
8
Differentiation in brain and liver DOPA/5HTP decarboxylase activity after L-DOPA administration with or without pyridoxine in cats.在猫体内，给予左旋多巴（L-DOPA）加或不加吡哆醇后，脑和肝脏中多巴/5-羟色氨酸脱羧酶活性的差异。
J Neurochem. 1977 Mar;28(3):479-85. doi: 10.1111/j.1471-4159.1977.tb10418.x.
9
Mammalian histidine decarboxylase and dopa decarboxylase.哺乳动物组氨酸脱羧酶和多巴脱羧酶。
Ann N Y Acad Sci. 1990;585:145-61. doi: 10.1111/j.1749-6632.1990.tb28050.x.
10
Variations in aromatic amino acid decarboxylase activity towards DOPA and 5-hydroxytryptophan caused by pH changes and denaturation.由pH变化和变性引起的芳香族氨基酸脱羧酶对多巴和5-羟色氨酸活性的变化。
J Neurochem. 1972 Dec;19(12):2801-10. doi: 10.1111/j.1471-4159.1972.tb03817.x.
引用本文的文献
1
The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review.多巴胺能系统内基因多态性与尼古丁依赖的关联：一篇叙述性综述。
Heliyon. 2024 Jun 15;10(12):e33158. doi: 10.1016/j.heliyon.2024.e33158. eCollection 2024 Jun 30.
2
Case report: Childhood epilepsy and borderline intellectual functioning hiding an AADC deficiency disorder associated with compound heterozygous gene pathogenic variants.病例报告：儿童癫痫和边缘智力功能障碍掩盖了一种与复合杂合基因致病性变异相关的芳香族氨基酸脱羧酶缺乏症。
Front Neurol. 2023 Dec 5;14:1284339. doi: 10.3389/fneur.2023.1284339. eCollection 2023.
3
RNA modification regulator DDC in endometrial cancer affects the tumor microenvironment and patient prognosis.RNA 修饰调节因子 DDC 在子宫内膜癌中影响肿瘤微环境和患者预后。
Sci Rep. 2023 Oct 23;13(1):18057. doi: 10.1038/s41598-023-44269-2.
4
A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting Neurons in Spinal Cords of Rodents, Carnivores, and Primates.PKD2L1 表达的脑脊液接触神经元在啮齿动物、食肉动物和灵长类动物脊髓中的比较。
Int J Mol Sci. 2023 Sep 1;24(17):13582. doi: 10.3390/ijms241713582.
5
Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.组织特异性 Grb10/Ddc 绝缘子驱动心脏发育的等位基因结构。
Mol Cell. 2022 Oct 6;82(19):3613-3631.e7. doi: 10.1016/j.molcel.2022.08.021. Epub 2022 Sep 14.
6
Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland.印迹基因在发育中和出生后垂体中的动态表达。
Genes (Basel). 2021 Mar 30;12(4):509. doi: 10.3390/genes12040509.
7
Revised Exon Structure of l-DOPA Decarboxylase () Reveals Novel Splice Variants Associated with Colorectal Cancer Progression.l-DOPA 脱羧酶 () 外显子结构的修订揭示了与结直肠癌进展相关的新型剪接变体。
Int J Mol Sci. 2020 Nov 13;21(22):8568. doi: 10.3390/ijms21228568.
8
Antidepressant-Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity.阿魏酸通过促进能量代谢活性产生抗抑郁样作用。
Mol Nutr Food Res. 2019 Oct;63(19):e1900327. doi: 10.1002/mnfr.201900327. Epub 2019 Aug 22.
9
Temporal Effects on Radiation Responses in Nonhuman Primates: Identification of Biofluid Small Molecule Signatures by Gas Chromatography⁻Mass Spectrometry Metabolomics.非人灵长类动物辐射反应的时间效应：通过气相色谱-质谱代谢组学鉴定生物流体小分子特征
Metabolites. 2019 May 15;9(5):98. doi: 10.3390/metabo9050098.
10
Embracing diversity in the 5-HT neuronal system.拥抱 5-HT 神经元系统中的多样性。
Nat Rev Neurosci. 2019 Jul;20(7):397-424. doi: 10.1038/s41583-019-0151-3.
本文引用的文献
1
Aromatic L-amino acid decarboxylase.芳香族L-氨基酸脱羧酶
J Biol Chem. 1962 Jan;237:89-93.
2
CONTROL OF THE CIRCADIAN RHYTHM IN SEROTONIN CONTENT OF THE RAT PINEAL GLAND.大鼠松果体血清素含量的昼夜节律控制。
Proc Natl Acad Sci U S A. 1965 Feb;53(2):301-5. doi: 10.1073/pnas.53.2.301.
3
Observations on the substrate specificity of DOPA decarboxylase from ox adrenal medulla, human phaeochromocytoma and human argentaffinoma.关于牛肾上腺髓质、人嗜铬细胞瘤和人嗜银细胞瘤中多巴脱羧酶底物特异性的观察
Br J Pharmacol Chemother. 1962 Feb;18(1):175-82. doi: 10.1111/j.1476-5381.1962.tb01161.x.
4
Activation of DOPA decarboxylase by pyridoxal phosphate.磷酸吡哆醛对多巴脱羧酶的激活作用。
Arch Biochem Biophys. 1962 Sep;98:520-5. doi: 10.1016/0003-9861(62)90220-5.
5
Studies on 5-hydroxy-tryptophan decarboxylase. II. Additional inhibition studies and suggestions on the nature of the enzymic site.5-羟色氨酸脱羧酶的研究。II. 进一步的抑制研究及对酶活性位点性质的推测
Arch Biochem Biophys. 1960 Jul;89:143-7. doi: 10.1016/0003-9861(60)90025-4.
6
[On the purification and specificity of DOPA-decarboxylase].[关于多巴脱羧酶的纯化及特异性]
Hoppe Seylers Z Physiol Chem. 1959 Sep 30;316:45-60. doi: 10.1515/bchm2.1959.316.1.45.
7
Purification and properties of adrenal L-DOPA decarboxylase.肾上腺L-多巴脱羧酶的纯化及性质
Enzymologia. 1959 Jul 15;20:366-76.
8
Are dihydroxphenylalanine decarboxylase and 5-hydroxytrptophan decarboxylase individual enzymes?二羟基苯丙氨酸脱羧酶和5-羟色氨酸脱羧酶是不同的酶吗？
Acta Physiol Scand. 1960 Aug 25;49:364-9. doi: 10.1111/j.1748-1716.1960.tb01958.x.
9
[Inhibition of serotonin formation by alpha-methyl-DOPA].[α-甲基多巴对血清素形成的抑制作用]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;234(3):194-205.
10
Observations on the intracellular granules of the adrenal medulla.关于肾上腺髓质细胞内颗粒的观察
J Physiol. 1955 Jul 28;129(1):27-49. doi: 10.1113/jphysiol.1955.sp005336.
Zotero 插件