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1
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).关于多巴脱羧酶和5-羟色氨酸脱羧酶的同一性（免疫滴定 - 芳香族L-氨基酸脱羧酶 - 血清素 - 多巴胺 - 去甲肾上腺素）
Proc Natl Acad Sci U S A. 1972 Feb;69(2):343-7. doi: 10.1073/pnas.69.2.343.
2
Ambivalence on the multiplicity of mammalian aromatic L-amino acid decarboxylase.对哺乳动物芳香族L-氨基酸脱羧酶多样性的矛盾态度。
Adv Exp Med Biol. 1991;294:115-25. doi: 10.1007/978-1-4684-5952-4_10.
3
Biochemical characteristics of mammalian brain 5-hydroxytryptophan decarboxylase activity.哺乳动物脑5-羟色氨酸脱羧酶活性的生化特性
Adv Biochem Psychopharmacol. 1974;11(0):43-50.
4
Rat brain L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan decarboxylase activities: differential effect of 6-hydroxydopamine.大鼠脑L-3,4-二羟基苯丙氨酸和L-5-羟色氨酸脱羧酶活性：6-羟基多巴胺的不同作用
Brain Res. 1973 Jan 15;49(1):165-75. doi: 10.1016/0006-8993(73)90408-3.
5
Role of catechol structure in the inhibitory effects of D-isomers of amino acids on the decarboxylation of L-5-hydroxytryptophan.儿茶酚结构在氨基酸D-异构体对L-5-羟色氨酸脱羧作用的抑制效应中的作用。
Experientia. 1978 Sep 15;34(9):1188-9. doi: 10.1007/BF01922950.
6
Characteristics of enzymic decarboxylation of L-threo-3,4-dihydroxyphenylserine using hog renal L-aromatic amino acid decarboxylase.使用猪肾L-芳香族氨基酸脱羧酶对L-苏式-3,4-二羟基苯丝氨酸进行酶促脱羧反应的特性。
Biochem Pharmacol. 1978 Apr 1;27(7):1081-6. doi: 10.1016/0006-2952(78)90161-2.
7
A possible feed-back mechanism controlling the biosynthesis of 5-hydroxytryptamine.一种可能控制5-羟色胺生物合成的反馈机制。
Biochem Pharmacol. 1967 Oct;16(10):1981-7. doi: 10.1016/0006-2952(67)90309-7.
8
Differentiation in brain and liver DOPA/5HTP decarboxylase activity after L-DOPA administration with or without pyridoxine in cats.在猫体内，给予左旋多巴（L-DOPA）加或不加吡哆醇后，脑和肝脏中多巴/5-羟色氨酸脱羧酶活性的差异。
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9
Mammalian histidine decarboxylase and dopa decarboxylase.哺乳动物组氨酸脱羧酶和多巴脱羧酶。
Ann N Y Acad Sci. 1990;585:145-61. doi: 10.1111/j.1749-6632.1990.tb28050.x.
10
Variations in aromatic amino acid decarboxylase activity towards DOPA and 5-hydroxytryptophan caused by pH changes and denaturation.由pH变化和变性引起的芳香族氨基酸脱羧酶对多巴和5-羟色氨酸活性的变化。
J Neurochem. 1972 Dec;19(12):2801-10. doi: 10.1111/j.1471-4159.1972.tb03817.x.

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本文引用的文献

1
Aromatic L-amino acid decarboxylase.芳香族L-氨基酸脱羧酶
J Biol Chem. 1962 Jan;237:89-93.
2
CONTROL OF THE CIRCADIAN RHYTHM IN SEROTONIN CONTENT OF THE RAT PINEAL GLAND.大鼠松果体血清素含量的昼夜节律控制。
Proc Natl Acad Sci U S A. 1965 Feb;53(2):301-5. doi: 10.1073/pnas.53.2.301.
3
Observations on the substrate specificity of DOPA decarboxylase from ox adrenal medulla, human phaeochromocytoma and human argentaffinoma.关于牛肾上腺髓质、人嗜铬细胞瘤和人嗜银细胞瘤中多巴脱羧酶底物特异性的观察
Br J Pharmacol Chemother. 1962 Feb;18(1):175-82. doi: 10.1111/j.1476-5381.1962.tb01161.x.
4
Activation of DOPA decarboxylase by pyridoxal phosphate.磷酸吡哆醛对多巴脱羧酶的激活作用。
Arch Biochem Biophys. 1962 Sep;98:520-5. doi: 10.1016/0003-9861(62)90220-5.
5
Studies on 5-hydroxy-tryptophan decarboxylase. II. Additional inhibition studies and suggestions on the nature of the enzymic site.5-羟色氨酸脱羧酶的研究。II. 进一步的抑制研究及对酶活性位点性质的推测
Arch Biochem Biophys. 1960 Jul;89:143-7. doi: 10.1016/0003-9861(60)90025-4.
6
[On the purification and specificity of DOPA-decarboxylase].[关于多巴脱羧酶的纯化及特异性]
Hoppe Seylers Z Physiol Chem. 1959 Sep 30;316:45-60. doi: 10.1515/bchm2.1959.316.1.45.
7
Purification and properties of adrenal L-DOPA decarboxylase.肾上腺L-多巴脱羧酶的纯化及性质
Enzymologia. 1959 Jul 15;20:366-76.
8
Are dihydroxphenylalanine decarboxylase and 5-hydroxytrptophan decarboxylase individual enzymes?二羟基苯丙氨酸脱羧酶和5-羟色氨酸脱羧酶是不同的酶吗？
Acta Physiol Scand. 1960 Aug 25;49:364-9. doi: 10.1111/j.1748-1716.1960.tb01958.x.
9
[Inhibition of serotonin formation by alpha-methyl-DOPA].[α-甲基多巴对血清素形成的抑制作用]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;234(3):194-205.
10
Observations on the intracellular granules of the adrenal medulla.关于肾上腺髓质细胞内颗粒的观察
J Physiol. 1955 Jul 28;129(1):27-49. doi: 10.1113/jphysiol.1955.sp005336.

关于多巴脱羧酶和5-羟色氨酸脱羧酶的同一性（免疫滴定 - 芳香族L-氨基酸脱羧酶 - 血清素 - 多巴胺 - 去甲肾上腺素）

On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).

作者信息

Christenson J G, Dairman W, Udenfriend S

出版信息

Proc Natl Acad Sci U S A. 1972 Feb;69(2):343-7. doi: 10.1073/pnas.69.2.343.

DOI:10.1073/pnas.69.2.343
PMID:4536745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC426454/
Abstract

Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.

摘要

对来自多种物种的多个组织中的多巴和5-羟色氨酸脱羧酶活性进行同步免疫滴定，结果表明，用针对猪肾脱羧酶的单特异性抗血清无法区分这两种活性。结合先前的研究结果，这些数据有力地证实了以下概念：在哺乳动物组织中，这两种酶活性与单一蛋白质相关，即芳香族L-氨基酸脱羧酶。