赭曲霉毒素A诱导的缺铁性贫血。
Ochratoxin A-induced iron deficiency anemia.
作者信息
Huff W E, Chang C F, Warren M F, Hamilton P B
出版信息
Appl Environ Microbiol. 1979 Mar;37(3):601-4. doi: 10.1128/aem.37.3.601-604.1979.
Abstract
Ochratoxin A at 8 micrograms per g of diet, but not at lower doses, fed to chickens from 1 day to 3 weeks of age resulted in significantly (P less than 0.05) decreased packed blood cell volume and hemoglobin concentration without altering the number of circulating erythrocytes. Serum iron and percentage of transferrin saturation were lowered at 4 and 8 micrograms/g. Therefore, anemia was characteristic of severe ochratoxicosis of young chickens, and the anemia was categorized as a hypochromic-microcytic anemia of the iron deficiency type. These data indicate that ochratoxin A by itself does not cause hemorrhagic anemia syndrome of chickens and that an anemia caused by a nutritional deficiency can be elicited by a mycotoxin.
摘要
从1日龄至3周龄给雏鸡饲喂每克日粮含8微克但不含更低剂量的赭曲霉毒素A，会导致血细胞压积和血红蛋白浓度显著降低（P<0.05），而循环红细胞数量未改变。每克含4微克和8微克时，血清铁和转铁蛋白饱和度百分比降低。因此，贫血是雏鸡严重赭曲霉毒素中毒的特征，且该贫血被归类为缺铁型低色素小细胞性贫血。这些数据表明，赭曲霉毒素A本身不会引起鸡的出血性贫血综合征，且一种由营养缺乏引起的贫血可由一种霉菌毒素诱发。
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