Jick H, Porter J, Morrison A S, Rothman K J
Arch Intern Med. 1979 Jul;139(7):745-6.
A comparison was made between cigarette smoking histories of 31 women below age 50 years who had a diagnosis of lung cancer on hospital discharge and smoking histories of 124 women below age 50 years who had been hospitalized for other conditions. Of the women with lung cancer, 28 (90%) were current or former cigarette smokers; 72 (58%) of the comparison women were smokers. The relative risk estimate for lung cancer among smokers as compared with nonsmokers is 6.7, with 90% confidence limits of 4.0 and 11. Risk of lung cancer increased with the amount that the women smoked. The smokers with lung cancer had been smoking for longer periods than the smokers with other conditions. Assuming that the association is causal, cigarette smoking was responsible for about 77% of the lung cancer of young women in this survey.
对31名50岁以下出院时被诊断为肺癌的女性的吸烟史与124名因其他疾病住院的50岁以下女性的吸烟史进行了比较。在患有肺癌的女性中，28名（90%）是目前或曾经的吸烟者；在对照组女性中，72名（58%）是吸烟者。吸烟者与不吸烟者相比患肺癌的相对风险估计值为6.7，90%置信区间为4.0至11。患肺癌的风险随着女性吸烟量的增加而增加。患有肺癌的吸烟者吸烟时间比患有其他疾病的吸烟者更长。假设这种关联是因果关系，在本次调查中，吸烟导致了年轻女性约77%的肺癌。
