Barrientos A, Perez-Diaz V, Diaz-Gonzalez R, Rodicio J L
Arch Intern Med. 1979 Jul;139(7):787-9.
Two patients with hypouricemia with high levels of uric acid in their urine were given pyrazinamide and probenecid. The uric acid clearance decreased to low or normal values after pyrazinamide administration. In both cases, probenecid produced a slight increment in the uric acid excretion. This type of response suggests a defect in the reabsorption component. It is tempting to speculate on a postsecretory reabsorption defect based on the results of pyrazinamide and probenecid tests.
两名低尿酸血症患者尿液中尿酸水平较高，给予了吡嗪酰胺和丙磺舒。服用吡嗪酰胺后，尿酸清除率降至低或正常水平。在这两种情况下，丙磺舒使尿酸排泄略有增加。这种反应类型提示重吸收成分存在缺陷。根据吡嗪酰胺和丙磺舒试验结果，很容易推测存在分泌后重吸收缺陷。
