Härtl A, Kirchner E, Horn U, Stöckel U, Güttner J, Hoffmann H
Arch Exp Veterinarmed. 1979 Jan;33(1):111-9.
Turimycin is characterised by low acute toxicity. Mean lethal doses for mouse and rat are 750 mg/kg body weight for intraperitoneal application of something in excess of 3,000 mg/kg for oral administration. The blood pressure of anaesthetised cats may be reduced by amounts depending on intravenous Turimycin doses (between 10 and 50 mg/kg). The hypotensive effect of Turimycin is attributable to its negative inotropic effect on the heart and its spasmolytic action on the unstriated muscles. Reversible reduction of urine and ion excretion of rat following intraperitoneal application of 50 mg/kg body weight of Turimycin is interpreted as a consequence of such action upon blood pressure. A preliminary study was conducted into dogs which had orally received daily Turimycin doses of 50 or 125 mg/kg body weight over twelve months. No substance-depending functional or morphological damage was recorded.
土霉素的特点是急性毒性低。小鼠和大鼠的平均致死剂量，腹腔注射为750毫克/千克体重，口服超过3000毫克/千克体重。麻醉猫的血压降低幅度取决于静脉注射土霉素的剂量（10至50毫克/千克）。土霉素的降压作用归因于其对心脏的负性肌力作用及其对平滑肌的解痉作用。大鼠腹腔注射50毫克/千克体重的土霉素后，尿液和离子排泄的可逆减少被解释为这种对血压作用的结果。对口服土霉素剂量为50或125毫克/千克体重，持续十二个月的狗进行了初步研究。未记录到与物质相关的功能或形态损伤。
