皮质类固醇对体外内毒素诱导的微凝块的影响。
The effect of corticosteroids on in vitro endotoxin-induced microclots.
作者信息
Juhlin L, Shelley W B, Vahlquist C
出版信息
Br J Dermatol. 1979 Apr;100(4):385-8. doi: 10.1111/j.1365-2133.1979.tb01638.x.
Abstract
The in vitro endotoxin-induced fibrin microclots could be completely inhibited in blood by treating the patient with an oral dose of 30--60 mg prednisone 24 h before drawing the blood sample. When added to 100 ml blood in vitro, the minimal inhibiting dose of corticosteroid is 0.004 mg betamethasone or 0.5 mg hydrocortisone.
摘要
在体外，内毒素诱导的纤维蛋白微凝块可通过在采集血样前24小时给患者口服30 - 60毫克泼尼松进行治疗而在血液中被完全抑制。当在体外添加到100毫升血液中时，皮质类固醇的最小抑制剂量为0.004毫克倍他米松或0.5毫克氢化可的松。
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