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1
Intra-arterial infusion with methotrexate in the rat.大鼠动脉内注射甲氨蝶呤
Br J Cancer. 1974 Oct;30(4):349-54. doi: 10.1038/bjc.1974.204.
2
Serum and cerebrospinal fluid distribution of 5-methyltetrahydrofolate after intravenous calcium leucovorin and intra-Ommaya methotrexate administration in patients with meningeal carcinomatosis.静脉注射亚叶酸钙和经奥马亚贮器鞘内注射甲氨蝶呤后，5-甲基四氢叶酸在脑膜癌病患者血清和脑脊液中的分布情况。
Cancer Res. 1983 Jan;43(1):435-8.
3
[Therapy of solid tumors using high-dose methotrexate and citrovorum factor].
Osterr Z Onkol. 1977;3(5-6):141-8.
4
[Intra-arterial infusion of high dose methotrexate therapy in recurrent gliomas].[高剂量甲氨蝶呤动脉内灌注治疗复发性胶质瘤]
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1461-6.
5
Treatment of primary osteosarcoma with intra-arterial and intravenous high-dose methotrexate.采用动脉内和静脉内高剂量甲氨蝶呤治疗原发性骨肉瘤。
J Clin Oncol. 1983 Jul;1(7):428-31. doi: 10.1200/JCO.1983.1.7.428.
6
Pharmacokinetics of tumor cell exposure to [14C]methotrexate after intracarotid administration without and with hyperosmotic opening of the blood-brain and blood-tumor barriers in rat brain tumors: a quantitative autoradiographic study.大鼠脑肿瘤经颈动脉给药后，在未开放和开放血脑屏障及血肿瘤屏障（通过高渗方法）的情况下，肿瘤细胞对[14C]甲氨蝶呤的药代动力学：一项定量放射自显影研究。
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Continuous intra-arterial infusion for treating Jensen sarcoma.持续动脉内输注治疗詹森肉瘤。
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[Intra-aortic infusion therapy with sequential methotrexate (MTX) and 5-FU in advanced gastric carcinoma].
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[Intra-arterial 5-FU/intra-venous MTX therapy for metastatic liver lesions].
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引用本文的文献

1
Pharmacokinetics of intra-arterial tumour therapy. An experimental study.动脉内肿瘤治疗的药代动力学。一项实验研究。
Arch Otorhinolaryngol. 1984;239(2):153-61. doi: 10.1007/BF00463556.
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[Animal experiments for intra-arterial chemotherapy with bleomycin (author's transl)].博来霉素动脉内化疗的动物实验（作者译）
Arch Otorhinolaryngol. 1980;228(4):271-83. doi: 10.1007/BF00660740.

本文引用的文献

1
DETERMINATIONS OF THE LEVELS OF SERUM FOLATE IN PATIENTS WITH CARCINOMA OF THE HEAD AND NECK TREATED WITH METHOTREXATE.对头颈部癌患者使用甲氨蝶呤治疗后血清叶酸水平的测定。
Cancer Res. 1964 Jan;24:105-13.
2
SYSTEMIC THERAPY WITH AMETHOPTERIN IN SQUAMOUS CARCINOMA OF THE HEAD AND NECK.氨甲蝶呤对头颈部鳞状细胞癌的全身治疗
Cancer Chemother Rep. 1963 Oct;32:47-54.
3
The use of methotrexate orally in treatment of squamous cancers of the head and neck.口服甲氨蝶呤治疗头颈部鳞状癌。
Cancer Chemother Rep. 1962 Feb;16:511-4.
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Antimetabolite-metabolite combination cancer chemotherapy. Effects of intraarterial methotrexate-intramuscular Citrovorum factor therapy in human cancer.抗代谢物-代谢物联合癌症化疗。动脉内注射甲氨蝶呤-肌肉注射亚叶酸钙疗法对人类癌症的疗效。
Cancer. 1959 Nov-Dec;12:1248-62. doi: 10.1002/1097-0142(195911/12)12:6<1248::aid-cncr2820120619>3.0.co;2-2.
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Studies on the management of mouse leukemia (L1210) with antagonists of folic acid.
Cancer Res. 1955 Dec;15(11):742-7.
6
Methotrexate (NSC-740) in squamous cell carcinoma of the head and neck. II. Intermittent intravenous therapy.甲氨蝶呤（NSC - 740）用于头颈部鳞状细胞癌。II. 间歇性静脉治疗。
Cancer Chemother Rep. 1967 Apr;51(2):69-72.
7
Treatment of advanced cancer of head and neck by large doses of methotrexate.大剂量甲氨蝶呤治疗晚期头颈癌
J Ir Med Assoc. 1971 Jul 22;64(416):376-9.
8
Experimental chemotherapy of a transplantable rhabdomyosarcoma in the rat.大鼠可移植性横纹肌肉瘤的实验性化疗
Eur J Cancer (1965). 1970 Oct;6(5):441-3. doi: 10.1016/0014-2964(70)90043-5.
9
Analysis of the results of regional chemotherapy for carcinomas of the orofacial region.
Neoplasma. 1970;17(1):85-92.
10
Head and neck cancer. 3. Toxicity of 24-hour infusions of methotrexate (NSC-740) and protection by leucovorin (NSC-3590) in patients with epidermoid carcinomas.头颈部癌。3. 甲氨蝶呤（NSC - 740）24小时输注的毒性及亚叶酸钙（NSC - 3590）对表皮样癌患者的保护作用。
Cancer Chemother Rep. 1967 Sep;51(5):305-11.

大鼠动脉内注射甲氨蝶呤

Intra-arterial infusion with methotrexate in the rat.

作者信息

Sindram P J, Snow G B, van Putten L M

出版信息

Br J Cancer. 1974 Oct;30(4):349-54. doi: 10.1038/bjc.1974.204.

DOI:10.1038/bjc.1974.204
PMID:4548653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009300/
Abstract

The superiority of intra-arterial infusion with methotrexate (MTX) over its systemic use in the treatment of head and neck tumours is still being questioned. A model in the rat, suitable for intra-arterial administration of MTX could be constructed. In this model 3 schedules have been investigated: (1) 7 days continuous intra-arterial infusion with MTX; (2) the same schedule combined with leucovorin (CF) 6-hourly intraperitoneally (i.p.) after Sullivan et al. (1959); (3) intermittent administration of MTX 2 × 24 h intra-arterial infusion on Day 1 and 4, while on Day 2, 3, 5, 6 and 7 the catheter is kept open by the continuous intra-arterial infusion of saline. For all the three schedules intra-arterial MTX proved to be superior to its systemic use.

摘要

甲氨蝶呤（MTX）动脉内灌注治疗头颈部肿瘤优于全身用药这一点仍受到质疑。可以构建一种适合MTX动脉内给药的大鼠模型。在该模型中研究了3种给药方案：（1）MTX连续7天动脉内灌注；（2）按照沙利文等人（1959年）的方法，在相同方案基础上每6小时腹腔内（i.p.）注射亚叶酸（CF）；（3）MTX间歇性给药，在第1天和第4天进行2次×24小时动脉内灌注，而在第2、3、5、6和7天通过持续动脉内灌注生理盐水保持导管开放。对于所有这三种给药方案，动脉内使用MTX均证明优于全身用药。