Friedheim E A
Bull World Health Organ. 1974;50(6):572-4.
The discovery in 1973 of a synergistic effect of the arsenical compound F 151, a macrofilaricide, and the benzimidazole compound HOE 33258, a microfilaricide, led to the preparation of the reaction product of F 151 and HOE 33258 (in the proportion 1 mol to 2 mol, respectively), which was designated by the letter E. This compound E proved to be an effective macro- and microfilaricidal agent when administered subcutaneously in a single well-tolerated dose to dogs that were naturally infected with Dirofilaria immitis.
1973年发现，杀成虫剂砷化合物F 151与杀微丝蚴剂苯并咪唑化合物HOE 33258具有协同作用，这促使人们制备了F 151与HOE 33258的反应产物（比例分别为1摩尔比2摩尔），并将其命名为化合物E。当以单一耐受良好的剂量皮下注射给自然感染犬恶丝虫的犬时，该化合物E被证明是一种有效的杀成虫和杀微丝蚴剂。
