Jeyaratnam J, Forshaw P J
Bull World Health Organ. 1974;51(5):531-5.
The claim that the hearts of animals chronically exposed to DDT are unduly sensitive to the cardiotoxic effects of vasopressin was reexamined. Rats and rabbits were fed a diet containing DDT for 8 months and were given weekly doses of vasopressin, which causes a temporary myocardial ischaemia. Electrocardiograms, recorded at 2-week intervals, showed no significant increase in the incidence of cardiac arrhythmias in the DDT-fed animals. Intravenous noradrenaline given at the end of the 8-month period did not produce a greater incidence of arrhythmias in the DDT-fed animals than in the controls. Isolated heart muscle preparations from the DDT-fed and control rats did not differ in their peak developed tensions and maximum rates of tension development. DDT, TDE, and DDE levels in heart muscle and fat were below detectable levels in the control rats, whereas in the DDT-fed rats they were at least 100 times those normally found in human tissues.
关于长期接触滴滴涕的动物心脏对加压素的心脏毒性作用过度敏感的说法，进行了重新研究。给大鼠和兔子喂食含滴滴涕的饲料8个月，并每周注射一次加压素，加压素会导致暂时性心肌缺血。每隔两周记录一次心电图，结果显示，喂食滴滴涕的动物心律失常的发生率没有显著增加。在8个月实验期结束时静脉注射去甲肾上腺素，喂食滴滴涕的动物心律失常的发生率并不比对照组更高。取自喂食滴滴涕的大鼠和对照大鼠的离体心肌标本，其最大张力峰值和张力发展的最大速率并无差异。对照大鼠心肌和脂肪中的滴滴涕、滴滴滴和滴滴伊水平低于可检测水平，而喂食滴滴涕的大鼠中这些物质的含量至少是人体组织中正常含量的100倍。
