鸽心线粒体中细胞色素b 566的需氧还原（琥珀酸-细胞色素C1还原酶-停流动力学）
Aerobic reduction of cytochrome b 566 in pigeon-heart mitochondria (succinate-cytochrome C1 reductase-stopped-flow kinetics).
作者信息
Erecińska M, Chance B, Wilson D F, Dutton P L
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):50-4. doi: 10.1073/pnas.69.1.50.
Abstract
In anaerobic, uncoupled pigeon-heart mitochondria treated with oxidizable substrate, the cytochrome b(566) remains largely oxidized. In the presence of antimycin A, addition of oxygen induces a reduction of this cytochrome. The rate of cytochrome b(566) reduction is comparable to and dependent on the rate of cytochrome c(1) oxidation. Kinetic data suggest that either ubiquinone or another donor of similar potential provides electrons for the reduction of cytochrome b(566). It is postulated that the aerobic reduction of cytochrome b(566) is directly related to the energy conservation at site II.
摘要
在用可氧化底物处理的厌氧、解偶联鸽心线粒体中，细胞色素b（566）大部分保持氧化状态。在抗霉素A存在的情况下，加入氧气会导致该细胞色素还原。细胞色素b（566）的还原速率与细胞色素c1的氧化速率相当且依赖于后者。动力学数据表明，泛醌或另一种具有类似电位的供体为细胞色素b（566）的还原提供电子。据推测，细胞色素b（566）的需氧还原与位点II处的能量守恒直接相关。
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本文引用的文献
1
Studies on the electron transfer system. XLV. Some effects of antimycin on cytochrome b.电子传递系统的研究。XLV. 抗霉素对细胞色素b的某些影响。
J Biol Chem. 1962 Jul;237:2384-90.
2
The reversible removal of cytochrome c from mitochondria.细胞色素c从线粒体的可逆性移除。
J Biol Chem. 1960 Feb;235:531-4.
3
4
Studies on the electron-transport system. 27. The respiratory activity of acetoneextracted beef-heart mitochondria: role of coenzyme Q and other lipids.电子传递系统的研究。27. 丙酮提取的牛心线粒体的呼吸活性：辅酶Q和其他脂质的作用。
Biochim Biophys Acta. 1961 Feb 18;47:358-77. doi: 10.1016/0006-3002(61)90297-9.
5
Two b cytochromes of pigeon heart mitochondria.鸽心脏线粒体的两种b型细胞色素。
FEBS Lett. 1971 Jun 24;15(3):209-212. doi: 10.1016/0014-5793(71)80313-7.
6
Involvement of water in electron transport in complexes III and IV of the mitochondrial electron transport chain.水参与线粒体电子传递链复合物III和IV中的电子传递。
Biochem Biophys Res Commun. 1966 Jul 6;24(1):1-9. doi: 10.1016/0006-291x(66)90401-3.
7
8
On the redox potentials of ubiquinone and cytochrome b in the respiratory chain.关于呼吸链中泛醌和细胞色素b的氧化还原电位
Eur J Biochem. 1969 Jul;9(4):519-25. doi: 10.1111/j.1432-1033.1969.tb00640.x.
9
Interactions of uncoupling agents and of antimycin A with cytochrome b in yeast and heart muscle preparation under anaerobic conditions.在厌氧条件下，解偶联剂和抗霉素A与酵母和心肌制剂中细胞色素b的相互作用。
Arch Biochem Biophys. 1970 Aug;139(2):370-9. doi: 10.1016/0003-9861(70)90489-3.
10
Oxidation-reduction midpoint potentials of the mitochondrial flavoproteins.线粒体黄素蛋白的氧化还原中点电位。
Biochem Biophys Res Commun. 1970 Oct 23;41(2):386-92. doi: 10.1016/0006-291x(70)90516-4.
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