酿酒酵母中乳清苷酸焦磷酸化酶的调控
Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae.
作者信息
Jund R, Lacroute F
出版信息
J Bacteriol. 1972 Jan;109(1):196-202. doi: 10.1128/jb.109.1.196-202.1972.
Abstract
Yeast mutants deficient in orotidine-5'-phosphate (OMP) pyrophosphorylase activity have been obtained. The gene encoding this enzyme is unlinked to the four pyrimidine genes previously described. The specific activity of OMP pyrophosphorylase remains constant under all of the physiological conditions used to repress, to derepress, or to induce pyrimidine biosynthesis. This enzyme appears, therefore, to escape the scheme of regulation by mixed repression and induction controlling the other enzymes of the pyrimidine pathway.
摘要
已获得尿苷-5'-磷酸（OMP）焦磷酸化酶活性缺陷的酵母突变体。编码该酶的基因与先前描述的四个嘧啶基因不连锁。在用于抑制、解除抑制或诱导嘧啶生物合成的所有生理条件下，OMP焦磷酸化酶的比活性保持恒定。因此，这种酶似乎不受控制嘧啶途径其他酶的混合抑制和诱导调控机制的影响。
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