Sanfilippo O, Daidone M G, Di Fronzo G, Silvestrini R
Cancer. 1979 Jun;43(6):2365-9. doi: 10.1002/1097-0142(197906)43:6<2365::aid-cncr2820430629>3.0.co;2-u.
The stimulation of RNA synthesis induced by estradiol has been studied on 60 breast cancers in short-term cultures. In the same tumors the estrogen receptor (ER) assay was carried out. In 35% of the cases studied the stimulating effect by estradiol in vitro was observed. The frequency of response to in vitro hormone treatment was higher (42%) in ER+ cancers and lower (25%) in ER- cancers. The specificity of the in vitro test was assessed by the use of tamoxifen.
在短期培养的60例乳腺癌中研究了雌二醇诱导的RNA合成刺激作用。对同一肿瘤进行了雌激素受体（ER）检测。在35%的研究病例中观察到了雌二醇在体外的刺激作用。雌激素受体阳性（ER+）的癌症对体外激素治疗的反应频率较高（42%），而雌激素受体阴性（ER-）的癌症反应频率较低（25%）。通过使用他莫昔芬评估体外试验的特异性。
