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骨髓瘤、霍奇金病患者血细胞以及正常肝脏培养细胞的细胞质免疫荧光。

Cytoplasmic immunofluorescence of blood cells from myeloma, Hodgkin's disease an cultured cells from normal liver.

作者信息

Bankole R O, Bates H A, Swaim W R, Amatuzio D S

出版信息

Br J Cancer. 1972 Feb;26(1):10-4. doi: 10.1038/bjc.1972.4.

DOI:10.1038/bjc.1972.4
PMID:4552373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008331/
Abstract

The immunofluorescent reaction of peripheral blood cells from 10 multiple myeloma, 10 Hodgkin's and 11 lymphosarcoma cases with antiviral (Rauscher) murine leukaemia (AMR) and antihuman stem cell leukaemia plasma (AHS) antisera was studied. Cells from 25 of these patients were reactive at least once with AMR and AHS or AHS alone. Absorption studies suggested that this cytoplasmic immunofluorescent reaction involved cellular isoantigens. Serial studies on multiple myeloma, Hodgkin's and lymphosarcoma cases with significant fluorescence, showed that the fluorescent cell count variation was correlated with the presence of active disease.

摘要

研究了10例多发性骨髓瘤、10例霍奇金病和11例淋巴肉瘤患者外周血细胞与抗鼠抗病毒(劳斯氏)白血病(AMR)抗血清和抗人干细胞白血病血浆(AHS)抗血清的免疫荧光反应。这些患者中有25例的细胞至少与AMR和AHS或仅与AHS发生过一次反应。吸收研究表明,这种细胞质免疫荧光反应涉及细胞同种抗原。对具有显著荧光的多发性骨髓瘤、霍奇金病和淋巴肉瘤病例进行的系列研究表明,荧光细胞计数变化与活动性疾病的存在相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6907/2008331/10f260c03cfb/brjcancer00352-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6907/2008331/10f260c03cfb/brjcancer00352-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6907/2008331/10f260c03cfb/brjcancer00352-0020-a.jpg

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本文引用的文献

1
APPLICATION OF IMMUNOFLUORESCENCE TO THE STUDY OF HUMAN LEUKEMIA.免疫荧光在人类白血病研究中的应用
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Further observations on the immunofluorescence of cells in human leukemia.关于人类白血病细胞免疫荧光的进一步观察
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The detection of iso-antigens on leukemic cells using the cytotoxicity test.运用细胞毒性试验检测白血病细胞上的同种抗原。
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Immunofluorescent studies of human leukemic cells with antiserum to a murine leukemic virus (Rauscher strain).
Blood. 1968 Mar;31(3):381-7.
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Chronic myelogenous leukemia in Hodgkin's disease: immunofluorescence of cells.霍奇金病中的慢性粒细胞白血病:细胞的免疫荧光
Cancer. 1971 Mar;27(3):569-73. doi: 10.1002/1097-0142(197103)27:3<569::aid-cncr2820270309>3.0.co;2-4.
6
Nonspecific staining: its control in immunofluorescence examination of soil.非特异性染色:土壤免疫荧光检查中的控制
Science. 1968 Nov 29;162(3857):1012-4. doi: 10.1126/science.162.3857.1012.