大肠杆菌B-r阿拉伯糖操纵子的诱导
Induction of the ara operon of Escherichia coli B-r.
作者信息
Doyle M E, Brown C, Hogg R W, Helling R B
出版信息
J Bacteriol. 1972 Apr;110(1):56-65. doi: 10.1128/jb.110.1.56-65.1972.
Abstract
The inducer specificity and kinetics of induction of the ara operon were examined in Escherichia coli B/r. A difference in the kinetics of induction was found between our B/r strains and the K-12 strain previously described by Schleif. The roles of active transport and metabolism of inducer, and of cell density, in induction were studied. d-Fucose and beta-methyl-l-arabinoside were competitive inhibitors of induction. No inducer of the wild-type strain other than l-arabinose was found. However, a procedure for selecting mutants with altered inducer affinity or specificity was developed. The properties of one such mutant (inducible by d-fucose) are described.
摘要
在大肠杆菌B/r中研究了阿拉伯糖操纵子的诱导物特异性和诱导动力学。我们发现B/r菌株与Schleif之前描述的K-12菌株在诱导动力学上存在差异。研究了诱导物的主动运输和代谢以及细胞密度在诱导过程中的作用。d-岩藻糖和β-甲基-L-阿拉伯糖苷是诱导的竞争性抑制剂。除L-阿拉伯糖外，未发现野生型菌株的其他诱导物。然而，开发了一种选择诱导物亲和力或特异性改变的突变体的方法。描述了一个这样的突变体（可被d-岩藻糖诱导）的特性。
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