Johnston D A, Bodey G P
Appl Microbiol. 1972 May;23(5):846-51. doi: 10.1128/am.23.5.846-851.1972.
A semiquantitative culture technique was used to monitor the microbial flora of the oropharynx of 30 patients receiving antibiotic prophylaxis in protected environment units. After institution of antibiotic prophylaxis, the median concentration of organisms in the oropharynx fell by 2 logs but gradually increased by 1 log and then remained stable. Neisseria spp., Micrococcus sp., and Streptococci were generally eradicated by the antibiotics but were replaced by Lactobacilli and yeast. Four of nine enteric organisms persisted despite in vitro sensitivity to the antibiotic regimens. Yeast were cultured from the initial specimens of only 17% of the 30 patients, but they were cultured subsequently from specimens of 80% of the 20 patients who remained in protected environment units for at least 8 weeks.
采用半定量培养技术监测30例在保护环境病房接受抗生素预防治疗患者的口咽微生物菌群。在开始抗生素预防治疗后，口咽中微生物的中位浓度下降了2个对数，但随后逐渐上升了1个对数，然后保持稳定。奈瑟菌属、微球菌属和链球菌通常被抗生素根除，但被乳酸杆菌和酵母菌取代。尽管9种肠道微生物在体外对抗生素方案敏感，但仍有4种持续存在。酵母菌仅从30例患者中17%的初始标本中培养出来，但随后从在保护环境病房至少停留8周的20例患者中80%的标本中培养出来。
