Di Fronzo G, Bertuzzi A, Ronchi E, Villani F P, Ronchetti L
Cancer Chemother Pharmacol. 1979;2(3):169-73. doi: 10.1007/BF00258290.
The consequences at the cardiac level of adriamycin treatment alone or in association with the cardiac glycoside beta-methyldigoxin, were evaluated with reference to the PEP/LVET ratio, heart rate, and minimum blood pressure. The variation usually seen in the PEP/LVET ratio when adriamycin is administered alone was not observed when pretreatment with beta-methyldigoxin was also given. A similar situation is found with variations in blood pressure and heart rate. From a pharmacokinetic point of view, this treatment scheme does not seem to affect the general behavior of the antibiotic.
参照射血前期（PEP）与左室射血时间（LVET）的比值、心率和最低血压，评估单独使用阿霉素或与强心苷β-甲基地高辛联合使用时对心脏的影响。单独使用阿霉素时，PEP/LVET比值通常会发生变化，但在给予β-甲基地高辛预处理后，未观察到这种变化。血压和心率变化也出现了类似情况。从药代动力学角度来看，这种治疗方案似乎不会影响抗生素的总体特性。
