儿童使用人用和马用流感疫苗的现场试验：保护作用和抗体滴度
Field trial with human and equine influenza vaccines in children: protection and antibody titres.
作者信息
Wesselius-de Casparis A, Masurel N, Kerrebijn K F
出版信息
Bull World Health Organ. 1972;46(2):151-7.
Abstract
A placebo-controlled influenza vaccination trial was carried out on 374 children in the winter of 1967-68. The children were randomly vaccinated with 300 CCA of A2/England/1/1966, 300 CCA of A/equine 2/Miami/1963, or with a placebo. During this winter an influenza outbreak occurred, caused by A2/Nederland/1968. The A2 vaccine yielded a protection rate of 58% (P = 0.02) and the A/equine 2 vaccine a rate of 19% (P = 0.33). Serological data revealed that all influenza infections occurred in subjects who had a pre-epidemic haemagglutination inhibition titre below 150. The antibody response against various human influenza A2 viruses and against the horse strain (A/equine 2) is discussed.
摘要
1967 - 1968年冬季，对374名儿童进行了一项安慰剂对照的流感疫苗接种试验。这些儿童被随机接种300鸡胚尿囊液（CCA）的A2/英格兰/1/1966、300 CCA的A/马2/迈阿密/1963，或接种安慰剂。在这个冬季，发生了由A2/荷兰/1968引起的流感爆发。A2疫苗的保护率为58%（P = 0.02），A/马2疫苗的保护率为19%（P = 0.33）。血清学数据显示，所有流感感染均发生在流行前血凝抑制效价低于150的受试者中。文中讨论了针对各种人类甲型流感病毒和马毒株（A/马2）的抗体反应。
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