多巴胺能系统是否参与促甲状腺激素释放激素诱导的体温过高及其被苯丙胺增强的过程？

Is a dopaminergic system involved in thyrotropin releasing hormone induced hyperthermia and in its potentiation by amphetamine?

Rips R, Desiles M, Puech A J

Unité de Pharmacologie Chimique de l'INSERM, Paris, France.

Prog Neuropsychopharmacol. 1979;3(4):337-44. doi: 10.1016/0364-7722(79)90044-4.

Abstract

A dose-related hyperthermia is obtained in mice with TRH administered intraperitoneally. 2. This hyperthermia is reinforced by amphetamine given at doses which usually cause hypothermia. 3. p-Chloroamphetamine and L-Dopa also reinforce TRH hyperthermia. Apomorphine is not significantly active. 4. TRH hyperthermia is lowered significantly by alpha-methyl-tyrosine and haloperidol but not significantly by pimozide and chlorpromazine. TRH + Amph hyperthermia is not lowered by any of the DA antagonists tested even at doses reversing Amph hyperthermia. Direct participation of DA receptors is then doubtful. 5. All these variations of temperature have their acme a 15 min except for reserpine which, given 22 hours before, potentiates TRH + Amph hyperthermia after 30 min.

摘要

给小鼠腹腔注射促甲状腺激素释放激素（TRH）可产生剂量相关的体温升高。2. 通常会导致体温降低的剂量的苯丙胺可增强这种体温升高。3. 对氯苯丙胺和左旋多巴也可增强TRH引起的体温升高。阿扑吗啡的作用不明显。4. α-甲基酪氨酸和氟哌啶醇可显著降低TRH引起的体温升高，但匹莫齐特和氯丙嗪的作用不明显。即使给予能逆转苯丙胺引起的体温降低的剂量，TRH + 苯丙胺引起的体温升高也不会被所测试的任何一种多巴胺拮抗剂降低。因此，多巴胺受体的直接参与值得怀疑。5. 除利血平外，所有这些体温变化在15分钟时达到峰值，利血平在提前22小时给药后，30分钟后可增强TRH + 苯丙胺引起的体温升高。