Haynes M E, Haynes D W, Williams R
J Clin Pathol. 1972 May;25(5):403-9. doi: 10.1136/jcp.25.5.403.
An electron microscope study was made of liver biopsy material obtained during life or shortly after death from 11 patients. In three of them, where serum was positive for Australia antigen (two had serum hepatitis and one active chronic hepatitis) the hepatocytes contained characteristic particles within membrane-bound cytoplasmic vesicles. The appearance of these particles was very similar to that of the Australia antigen particles found in the serum. Two sizes of cytoplasmic particles were observed, with average diameters of about 26 and 46 nm. Particles of both sizes often had a membrane-like outer component and a moderately electron-dense inner component. They differed in both size and structure from the mainly intranuclear particles described by previous authors and which were not found in the present patients. The nature of the vesicles containing the particles was not apparent.
对11例患者生前或死后不久获取的肝活检材料进行了电子显微镜研究。其中3例患者血清澳大利亚抗原呈阳性（2例为血清性肝炎，1例为活动性慢性肝炎），其肝细胞的膜结合细胞质小泡内含有特征性颗粒。这些颗粒的外观与血清中发现的澳大利亚抗原颗粒非常相似。观察到两种大小的细胞质颗粒，平均直径约为26纳米和46纳米。两种大小的颗粒通常都有类似膜的外层成分和中等电子密度的内层成分。它们在大小和结构上与先前作者描述的主要位于核内的颗粒不同，且在本研究患者中未发现。含有颗粒的小泡的性质尚不明确。
