吗啡依赖的神经解剖学关联
Neuroanatomical correlates of morphine dependence.
作者信息
Wei E, Loh H H, Way E L
出版信息
Science. 1972 Aug 18;177(4049):616-7. doi: 10.1126/science.177.4049.616.
PMID:4558902
Abstract
Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.
摘要
盐酸纳洛酮是一种阿片类拮抗剂，被应用于吗啡依赖大鼠的几个离散脑区以引发戒断反应。给药后，丘脑出现了严重的戒断症状，但大脑的新皮质、海马体、下丘脑或被盖区未出现。
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