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吗啡依赖的神经解剖学关联

Neuroanatomical correlates of morphine dependence.

作者信息

Wei E, Loh H H, Way E L

出版信息

Science. 1972 Aug 18;177(4049):616-7. doi: 10.1126/science.177.4049.616.

DOI:10.1126/science.177.4049.616
PMID:4558902
Abstract

Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.

摘要

盐酸纳洛酮是一种阿片类拮抗剂，被应用于吗啡依赖大鼠的几个离散脑区以引发戒断反应。给药后，丘脑出现了严重的戒断症状，但大脑的新皮质、海马体、下丘脑或被盖区未出现。

相似文献

1
Neuroanatomical correlates of morphine dependence.吗啡依赖的神经解剖学关联
Science. 1972 Aug 18;177(4049):616-7. doi: 10.1126/science.177.4049.616.
2
Neuroanatomical and chemical correlates of naloxone-precipitated withdrawal.纳洛酮诱发戒断反应的神经解剖学和化学关联
Adv Biochem Psychopharmacol. 1973;8(0):455-69.
3
Brain sites of precipitated abstinence in morphine-dependent rats.吗啡依赖大鼠中诱发戒断反应的脑区
J Pharmacol Exp Ther. 1973 Apr;185(1):108-15.
4
The actions of narcotic antagonists in morphine-dependent rhesus monkeys.麻醉拮抗剂在吗啡依赖恒河猴体内的作用。
Adv Biochem Psychopharmacol. 1973;8(0):273-89.
5
Changes in brain cyclic AMP metabolism and acetylcholine and dopamine during narcotic dependence and withdrawal.麻醉药物依赖和戒断期间脑内环磷酸腺苷代谢、乙酰胆碱及多巴胺的变化
Life Sci. 1975 Jun 15;16(12):1889-94. doi: 10.1016/0024-3205(75)90297-0.
6
Central sites of naloxone-precipitated shaking in the anesthetized, morphine-dependent rat.纳洛酮诱发麻醉吗啡依赖大鼠颤抖的中枢部位
J Pharmacol Exp Ther. 1975 Dec;195(3):480-7.
7
A single-dose suppression test in morphine-dependent mice.吗啡依赖小鼠的单剂量抑制试验。
Proc Soc Exp Biol Med. 1974 Apr;145(4):1232-5. doi: 10.3181/00379727-145-37987.
8
Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor.环磷酸腺苷系统在小鼠吗啡身体依赖性中的作用：磷酸二酯酶4抑制剂咯利普兰对吗啡依赖性发展的预防作用
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[Precipitation and prevention of abstinence in acutely morphinized rats and mice: comparisons between naloxone, naltrexone, and diprenorphine (author's transl)].急性吗啡化大鼠和小鼠中戒断反应的诱发与预防：纳洛酮、纳曲酮和二丙诺啡之间的比较（作者译）
Psychopharmacology (Berl). 1976 Aug 26;49(1):41-8.
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Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain.吗啡依赖与大鼠脑内神经肽 S 受体表达和功能的变化有关。
Peptides. 2013 Aug;46:6-12. doi: 10.1016/j.peptides.2013.05.001. Epub 2013 May 16.

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Daily treatment with the dual orexin receptor antagonist DORA-12 during oxycodone abstinence decreases oxycodone conditioned reinstatement.在氧可酮戒断期间每日使用双重食欲素受体拮抗剂 DORA-12 治疗可减少氧可酮条件性复吸。
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Anterior cingulate cortex and its projections to the ventral tegmental area regulate opioid withdrawal, the formation of opioid context associations and context-induced drug seeking.
前扣带回皮质及其向腹侧被盖区的投射调节阿片类药物戒断、阿片类药物情境关联的形成以及情境诱导的药物寻求。
Front Neurosci. 2022 Aug 5;16:972658. doi: 10.3389/fnins.2022.972658. eCollection 2022.
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Opiate pharmacology and relief of pain.阿片类药物药理学与疼痛缓解
J Clin Oncol. 2014 Jun 1;32(16):1655-61. doi: 10.1200/JCO.2013.53.1079. Epub 2014 May 5.
5
Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor.环磷酸腺苷系统在小鼠吗啡身体依赖性中的作用：磷酸二酯酶4抑制剂咯利普兰对吗啡依赖性发展的预防作用
Br J Pharmacol. 2001 Mar;132(5):1111-7. doi: 10.1038/sj.bjp.0703912.
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Suppression of naloxone-precipitated withdrawal jumps in morphine-dependent mice by stimulation of prostaglandin EP3 receptor.通过刺激前列腺素EP3受体抑制吗啡依赖小鼠中纳洛酮诱发的戒断跳跃反应。
Br J Pharmacol. 1995 Nov;116(6):2661-6. doi: 10.1111/j.1476-5381.1995.tb17223.x.
7
Acute and chronic opiate effects on single units and EEG of medial thalamus and hippocampus: a latency analysis.急性和慢性阿片类药物对内侧丘脑和海马体单个神经元及脑电图的影响：潜伏期分析
Psychopharmacology (Berl). 1980;71(1):11-20. doi: 10.1007/BF00433246.
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Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats.有证据表明，前脑内的5-羟色胺参与了吗啡依赖大鼠中纳洛酮诱发的跳跃反应。
Br J Pharmacol. 1983 Aug;79(4):993-6. doi: 10.1111/j.1476-5381.1983.tb10546.x.
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Lowered seizure threshold as a part of the narcotic abstinence syndrome in rats.
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Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal.伏隔核作为阿片类药物戒断厌恶刺激效应的一个底物。
Psychopharmacology (Berl). 1989;98(4):530-4. doi: 10.1007/BF00441954.