三种三环类抗抑郁药：丙咪嗪、阿米替林和多塞平的心血管毒性比较。
Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
作者信息
Brown T C, Leversha A
出版信息
Clin Toxicol. 1979 Mar;14(3):253-6. doi: 10.3109/15563657908992441.
PMID:455914
Abstract
Experiments were conducted on puppies to compare the cardiovascular toxicity of imipramine, amitriptyline, and doxepin. The drugs were infused at weekly intervals to produce arrhythmias and/or hypotension. Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin.
摘要
在幼犬身上进行了实验，以比较丙咪嗪、阿米替林和多塞平的心血管毒性。每周间隔注射这些药物以诱发心律失常和/或低血压。对于给定剂量，丙咪嗪比阿米替林或多塞平诱发心律失常的可能性更小，且导致的血压下降幅度更小。
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