Strbak V, Greer M A
Endocrinology. 1979 Aug;105(2):488-9. doi: 10.1210/endo-105-2-488.
Hypothalamic ablation was performed at various periods postnatally in animals previously administered propylthiouracil to raise plasma TSH concentrations. There was no significant change in plasma Tsh up to 8 h after hypothalamic ablation in pups 1--4 days old, whereas hypophysectomy of such pups produced a 60% fall in plasma TSH within 4 h. By the 5th postnatal day, hypothalamic ablation produced a 30% fall in plasma TSH within 4 h (P less than 0.05). By the 12th postnatal day and thereafter, the fall in plasma TSH after hypothalamic ablation was not significantly different from that seen in adults, except in 30-day-old rats in which there was a lesser effect of hypothalamic ablation on plasma TSH (P less than 0.01 in comparison to 23-day-old and adult groups). The greatest effect of hypothalamic ablation on plasma TSH was in 45-day-old animals (P less than 0.01 in comparison to adults). No significant change was produced in plasma PRL within 4 h postoperatively at any age. Our data indicate that regulation of TSH secretion in the rat is independent of hypothalamic control until after the 5th postnatal day and is fully developed by day 12. This corresponds temporally with the postnatal rise of plasma TSH, T4, and T3 and hypothalamic TRH to adult concentrations and indicates maturation of the hypothalamic regulation of TSH secretion.
对先前给予丙硫氧嘧啶以提高血浆促甲状腺激素（TSH）浓度的动物，在出生后的不同时期进行下丘脑损毁。1至4日龄幼崽在进行下丘脑损毁后8小时内，血浆TSH无显著变化，而对这些幼崽进行垂体切除后，4小时内血浆TSH下降60%。到出生后第5天，下丘脑损毁在4小时内使血浆TSH下降30%（P<0.05）。到出生后第12天及之后，下丘脑损毁后血浆TSH的下降与成年动物所见无显著差异，30日龄大鼠除外，其中下丘脑损毁对血浆TSH的影响较小（与23日龄和成年组相比，P<0.01）。下丘脑损毁对血浆TSH的最大影响出现在45日龄动物中（与成年动物相比，P<0.01）。在任何年龄，术后4小时内血浆催乳素（PRL）均无显著变化。我们的数据表明，大鼠TSH分泌的调节在出生后第5天之前独立于下丘脑控制，到第12天完全发育。这在时间上与血浆TSH、T4和T3以及下丘脑促甲状腺激素释放激素（TRH）升至成年浓度相对应，表明下丘脑对TSH分泌的调节成熟。
