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[脑组织中微小超慢振荡与能量供应水平之间的关系]

[Relationship between the minute superslow oscillations and the level of energy supply in brain tissue].

作者信息

Borodkin Iu S, Lapina I A, Gogolitsyn Iu L, Bul'on V V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1979 Mar;65(3):336-43.

PMID:456652
Abstract

In animals, an increase in glycolysis intensity and processes of oxidative phosphorylation in the brain correlated with the steady potential shifts within the range of 0--1.0 Hz in the neocortex, dorsal hippocampus, and thalamic nuclei. The neurotropic drug ethymizol revealed two effects depending on the initial functional state of the rabbit: 2.5 mg/kg of the drug enhanced the amplitude of the minute waves in the frontal neocortex and dorsal hippocampus, increasing the metabolic rate in the unsteady period of conditioning, whereas after the fast conditioning the drug rendered background values to the minute oscillations and elongated the extinction of conditioned reflexes. The ethymizol appears to be an unspecific connector.

摘要

在动物中,大脑中糖酵解强度和氧化磷酸化过程的增加与新皮层、背侧海马体和丘脑核中0-1.0赫兹范围内的稳定电位变化相关。神经营养药物乙嘧唑根据兔子的初始功能状态显示出两种作用:2.5毫克/千克的该药物增强了额叶新皮层和背侧海马体中微小波的振幅,提高了条件反射不稳定期的代谢率,而在快速条件反射后,该药物使微小振荡恢复到背景值,并延长了条件反射的消退时间。乙嘧唑似乎是一种非特异性连接物。

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