将诺卡氏菌属微生物的细胞质提取物用于皮肤迟发反应，以此作为诺卡氏菌感染的诊断和流行病学研究手段。
Delayed skin reactions to cytoplasmic extracts of Nocardia organisms as a means of diagnosis and epidemiological study of Nocardia infection.
作者信息
Ortiz-Ortiz L, Bojalil L F
出版信息
Clin Exp Immunol. 1972 Oct;12(2):225-9.
Purified cytoplasmic extracts were prepared from and micro-organisms. They contained protein, carbohydrate and nucleic acid material. When these extracts were utilized as skin test antigens in individuals infected with , a delayed hypersensitivity reaction was observed. Cross reactivity occurred between the antigens, but the inflammatory reaction was usually larger with extracts obtained from the infecting micro-organism. On the other hand, low reactivity, if any, was observed when the same antigens were assayed in patients with tuberculosis and leprosy or in healthy individuals. In addition, the cytoplasmic extract from appeared useful in epidemiological studies, since skin reactivity was shown by individuals working or living in areas in which was isolated from the soil.
从[微生物名称1]和[微生物名称2]微生物中制备了纯化的细胞质提取物。它们含有蛋白质、碳水化合物和核酸物质。当这些提取物用作感染[微生物名称3]的个体的皮肤试验抗原时，观察到迟发型超敏反应。[微生物名称1]和[微生物名称2]的抗原之间存在交叉反应，但从感染微生物获得的提取物引发的炎症反应通常更大。另一方面，在结核病和麻风病患者或健康个体中检测相同抗原时，观察到的反应性较低（如果有的话）。此外，[微生物名称1]的细胞质提取物在流行病学研究中似乎有用，因为在从土壤中分离出[微生物名称1]的地区工作或生活的个体表现出皮肤反应性。
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