Reuber M D
Digestion. 1979;19(1):42-7. doi: 10.1159/000198320.
The maximal tolerated doses of dihydrosafrole, safrole, and isosafrole were given by continuous oral administration, starting at the age of 7 days, to both sexes of two hybrid strains of mice - (C57BL/6 X C3HAnf)F1 and (C57BL/6 X AKR)F1. Hyperplasia and carcinomas of the forestomach were significantly increased in female mice of both strains and in male mice of the latter strain ingesting dihydrosafrole. By contrast, neoplasms of the forestomach were not increased in mice receiving safrole or isosafrole. Mice with neoplasms of the stomach generally did not have neoplasms of the liver.
从7日龄开始，对两种杂交品系小鼠（C57BL/6×C3HAnf）F1和（C57BL/6×AKR）F1的雌雄小鼠连续口服二氢黄樟素、黄樟素和异黄樟素的最大耐受剂量。在摄入二氢黄樟素的两种品系雌性小鼠和后一品系雄性小鼠中，前胃增生和癌显著增加。相比之下，接受黄樟素或异黄樟素的小鼠前胃肿瘤没有增加。患有胃肿瘤的小鼠通常没有肝脏肿瘤。
