Sievers S, Dallenbach-Hellweg G, Schaude H
Geburtshilfe Frauenheilkd. 1979 May;39(5):389-92.
The local administration of progestional agents for the treatment of adenomatous hyperplasia of the endometrium is insufficient for two reasons: 1. The locally applied progestational agent does not reach the total surface of the endometrium especially not in the uterine fundus or in the tubal cornua. This is frequently due to uterine myomata and to the T-shape of the intra-uterine device which does not contain progestational agents within the T. 2. The progestational agent released by the intra-uterine device does not reach the deeper layers of the endometrium. It is therefore possible that the deeper layers of the endometrium undergo malignant change. At present it is therefore necessary to administer progestational agents in the treatment of adenotamous hyperplasias of the endometrium systemically.
局部应用孕激素治疗子宫内膜腺瘤样增生不足，原因有二：1. 局部应用的孕激素无法覆盖子宫内膜的整个表面，尤其是子宫底部或输卵管角部。这通常是由于子宫肌瘤以及不含孕激素的T形宫内节育器的形状所致。2. 宫内节育器释放的孕激素无法到达子宫内膜的深层。因此，子宫内膜深层有可能发生恶变。所以目前在治疗子宫内膜腺瘤样增生时，有必要全身应用孕激素。
