Gitel S N, Grieco A J, Wessler S, Snyderman S E
Haemostasis. 1979;8(1):54-7. doi: 10.1159/000214291.
The antimetabolite 6-azauridine blocks the de novo synthesis of pyrimidines and causes increased serum levels of several amino acids including homocystine. 6-Azauridine was was withdrawn from clinical use for the treatment of psoriasis because of the occurence of arterial and venous thromboembolic episodes in some psoriatic patients. Utilizing a standard animal model for the recognition of venous and arterial thrombosis, 6-azauridine was demonstrated in this study to cause thrombosis without producing homocystinemia when administered orally or intravenously.
抗代谢物6-氮杂尿苷可阻断嘧啶的从头合成，并导致包括同型胱氨酸在内的几种氨基酸的血清水平升高。由于一些银屑病患者出现动静脉血栓栓塞事件，6-氮杂尿苷已停止用于银屑病治疗的临床应用。利用一种识别静脉和动脉血栓形成的标准动物模型，本研究证明，口服或静脉注射6-氮杂尿苷可导致血栓形成，而不会产生高同型胱氨酸血症。
