Naismith W C, Barr W, MacVicar J
Br Med J. 1972 Nov 25;4(5838):461-2. doi: 10.1136/bmj.4.5838.461.
In a group of 20 matched primigravid patients labour was induced by forewater amniotomy followed by intravenous oxytocin (Syntocinon) administered in escalating doses. Ten of these patients, in a double-blind trial, also received prostaglandin E(2) infused simultaneously with the oxytocin. In the combined prostaglandin-oxytocin group there was a noticeable reduction in the dosage of oxytocin required to produce effective uterine action, and the duration of labour was also reduced. No side effects were observed.
在一组20例配对的初产妇中，通过人工破膜（前羊水），随后静脉滴注剂量递增的缩宫素（催产素）来引产。在一项双盲试验中，其中10例患者还在滴注缩宫素的同时静脉滴注前列腺素E₂。在前列腺素-缩宫素联合应用组中，产生有效子宫收缩所需的缩宫素剂量明显减少，产程也缩短。未观察到副作用。
