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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Buse M G, Atwell R, Mancusi V

Horm Metab Res. 1979 Apr;11(4):289-92.

The effect of a single i.p injection of branched chain amino acids on ribosomal profiles of psoas muscles was studied in rats after a 48--96 hour fast. Experimental and control animals received glucose and insulin 1--2 hours before killing. 2) The ratio of polysomes to subunits and monomers decreased progressively during the fast. 3) The administration of the three branched chain amino acids together or leucine alone significantly increased the proportion of polysomes. 4) This effect was not observed in rats fed ad libitum. 5) It is suggested that the branched chain amino acids and specifically leucine may be required for the full protein anabolic response of muscles to insulin during a prolonged fast.

在禁食48至96小时的大鼠中，研究了单次腹腔注射支链氨基酸对腰大肌核糖体图谱的影响。实验动物和对照动物在处死前1至2小时接受葡萄糖和胰岛素。2) 在禁食期间，多核糖体与亚基和单体的比例逐渐下降。3) 一起给予三种支链氨基酸或单独给予亮氨酸可显著增加多核糖体的比例。4) 在自由进食的大鼠中未观察到这种效应。5) 有人提出，在长期禁食期间，肌肉对胰岛素的充分蛋白质合成代谢反应可能需要支链氨基酸，特别是亮氨酸。

Buse M G, Atwell R, Mancusi V

Horm Metab Res. 1979 Apr;11(4):289-92.

The effect of a single i.p injection of branched chain amino acids on ribosomal profiles of psoas muscles was studied in rats after a 48--96 hour fast. Experimental and control animals received glucose and insulin 1--2 hours before killing. 2) The ratio of polysomes to subunits and monomers decreased progressively during the fast. 3) The administration of the three branched chain amino acids together or leucine alone significantly increased the proportion of polysomes. 4) This effect was not observed in rats fed ad libitum. 5) It is suggested that the branched chain amino acids and specifically leucine may be required for the full protein anabolic response of muscles to insulin during a prolonged fast.

在禁食48至96小时的大鼠中，研究了单次腹腔注射支链氨基酸对腰大肌核糖体图谱的影响。实验动物和对照动物在处死前1至2小时接受葡萄糖和胰岛素。2) 在禁食期间，多核糖体与亚基和单体的比例逐渐下降。3) 一起给予三种支链氨基酸或单独给予亮氨酸可显著增加多核糖体的比例。4) 在自由进食的大鼠中未观察到这种效应。5) 有人提出，在长期禁食期间，肌肉对胰岛素的充分蛋白质合成代谢反应可能需要支链氨基酸，特别是亮氨酸。