Livesley B, Catley P F, Campbell R C, Oram S
Br Med J. 1973 Feb 17;1(5850):375-8. doi: 10.1136/bmj.1.5850.375.
In the treatment of angina pectoris a double-blind evaluation of verapamil (Cordilox) at two dose levels-namely, 80 mg thrice daily and 120 mg thrice daily-propranolol (Inderal) 100 mg thrice daily, and isosorbide dinitrate (Vascardin) 20 mg thrice daily has been made against a placebo. The assessment was based on relief from daily attacks of angina on effort and the response to a whole-body exercise test. We can find no statistically significant difference between the effects of verapamil (120 mg three times a day) and propranolol (100 mg three times a day) in the treatment of angina of effort. Both of these preparations are more effective than a placebo both in the reduction of daily attacks (P < 0.01) and in the prolongation of exercise test (P < 0.05). Isosorbide dinitrate (20 mg three times a day) appears to be no more effective than a placebo in the treatment of angina on effort, but 14 out of 32 patients experienced headache of such severity that even when the dose was reduced to 10 mg thrice daily this drug therapy had to be withdrawn. Both propranolol (100 mg three times a day) and verapamil (120 mg three times a day) had a significant lowering effect on the diastolic blood pressure as measured with the patient standing (P < 0.01).
在心绞痛治疗中，针对安慰剂，对两种剂量水平的维拉帕米（异搏定）——即每日三次，每次80毫克和每日三次，每次120毫克——普萘洛尔（心得安）每日三次，每次100毫克，以及硝酸异山梨酯（消心痛）每日三次，每次20毫克进行了双盲评估。评估基于努力时每日心绞痛发作的缓解情况以及对全身运动试验的反应。我们发现在劳力性心绞痛治疗中，维拉帕米（每日三次，每次120毫克）和普萘洛尔（每日三次，每次100毫克）的效果之间没有统计学上的显著差异。这两种制剂在减少每日发作次数（P < 0.01）和延长运动试验时间（P < 0.05）方面都比安慰剂更有效。硝酸异山梨酯（每日三次，每次20毫克）在劳力性心绞痛治疗中似乎并不比安慰剂更有效，但32名患者中有14名经历了严重的头痛，以至于即使将剂量减至每日三次，每次10毫克，这种药物治疗也不得不停用。普萘洛尔（每日三次，每次100毫克）和维拉帕米（每日三次，每次120毫克）在患者站立时测量的舒张压方面都有显著的降低作用（P < 0.01）。
