The deficiency of cyclic AMP responsive G1 controls in cultured malignant liver epithelial cells.
作者信息
Williams G M
机构信息
Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, New York 10595.
出版信息
Cancer Lett. 1977 Mar;2(4-5):239-46. doi: 10.1016/s0304-3835(77)80028-1.
PMID:45726
Abstract
Normal rat liver epithelial cells in culture were blocked outside the S phase by dibutyryl cyclic AMP while malignant rat liver epithelial cells were slowed in S phase. It is suggested that this lack of normal response to a growth inhibitory factor by malignant cells may underly their relatively autonomous growth behavior.
摘要
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