皮肤血管炎患者纤溶治疗效果的临床与实验室双盲研究
Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis.
作者信息
Dodman B, Cunliffe W J, Roberts B E, Sibbald R
出版信息
Br Med J. 1973 Apr 14;2(5858):82-4. doi: 10.1136/bmj.2.5858.82.
Abstract
The effects of phenformin and ethyloestrenol and phenformin and stanozolol on the clinical state, plasma fibrinolytic activity, and fibrinogen-fibrin-related antigen (F.R.-antigen) were compared with placebo in 13 patients with cutaneous vasculitis. Eight patients showed considerable clinical improvement when taking phenformin and an anabolic steroid; an impaired fibrinolytic activity before treatment favoured clinical improvement.
摘要
在13例皮肤血管炎患者中，将苯乙双胍与乙基雌烯醇、苯乙双胍与司坦唑醇联用对临床状态、血浆纤溶活性以及纤维蛋白原 - 纤维蛋白相关抗原（F.R. - 抗原）的影响与安慰剂进行了比较。8例患者在服用苯乙双胍和一种合成代谢类固醇时临床症状有显著改善；治疗前纤溶活性受损有利于临床症状改善。
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Fibrinogen titre, fibrinolysis and platelet stickiness correlated with capillary bleeding or block in the skin.纤维蛋白原滴度、纤维蛋白溶解及血小板黏附性与皮肤毛细血管出血或阻塞相关。
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Fibrinolytic activity and haemagglutination inhibition immunoassays.纤维蛋白溶解活性和血凝抑制免疫测定
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The role of immune complexes and complement in tissue injury.免疫复合物和补体在组织损伤中的作用。
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