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1
Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis.皮肤血管炎患者纤溶治疗效果的临床与实验室双盲研究
Br Med J. 1973 Apr 14;2(5858):82-4. doi: 10.1136/bmj.2.5858.82.
2
The role of phenformin and ethyloestrenol or stanozolol in the treatment of decreased fibrinolytic states. (Cutaneous vasculitis, Raynaud's disease, Behcet's syndrome, recurrent deep vein thrombosis and post myocardial infarction).
Acta Univ Carol Med Monogr. 1972;52:19-23.
3
The association between cutaneous vasculitis and decreased blood fibrinolytic activity.
Br J Dermatol. 1971 Feb;84(2):99-105. doi: 10.1111/j.1365-2133.1971.tb06850.x.
4
Mode of action of phenformin plus ethyloestrenol on fibrinolysis.苯乙双胍加乙基雌烯醇对纤维蛋白溶解的作用方式。
Lancet. 1971 Apr 10;1(7702):723-5. doi: 10.1016/s0140-6736(71)91989-1.
5
Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic systems.苯乙双胍与乙基雌烯醇联合治疗对凝血和纤溶系统的影响。
J Clin Pathol. 1972 Jul;25(7):638-9. doi: 10.1136/jcp.25.7.638.
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Pharmacological stimulation of fibrinolytic activity in the surgical patient.外科手术患者纤溶活性的药理刺激。
Lancet. 1971 Apr 17;1(7703):774-6. doi: 10.1016/s0140-6736(71)91215-3.
7
Idiopathic recurrent superficial thrombophlebitis: treatment with fibrinolytic enhancement.特发性复发性浅表血栓性静脉炎：纤维蛋白溶解增强疗法。
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8
Preliminary report of beneficial effect of phenformin in combination with ethyloestrenol in treatment of cutaneous vasculitis and Behçet's syndrome.苯乙双胍与乙基雌烯醇联合治疗皮肤血管炎和白塞综合征疗效的初步报告
Postgrad Med J. 1969 May;45:62-6.
9
Fibrinolytic therapy for vasculitis of atrophie blanche.
Arch Dermatol. 1974 May;109(5):664-7.
10
Phenformin and ethyloestrenol for Raynaud's disease.苯乙双胍和乙基雌烯醇治疗雷诺氏病。
Lancet. 1969 Oct 25;2(7626):906-7. doi: 10.1016/s0140-6736(69)92364-2.

引用本文的文献

1
Effect of fibrinolytic treatment in malignant atrophic papulosis.纤溶治疗在恶性萎缩性丘疹病中的作用。
Br Med J. 1975 Aug 16;3(5980):415. doi: 10.1136/bmj.3.5980.415.
2
Prophylactic agents for thrombosis.血栓形成的预防剂。
Drugs. 1975;9(1):1-3. doi: 10.2165/00003495-197509010-00001.
3
Cutaneous angiitis.皮肤血管炎
J R Coll Physicians Lond. 1975 Jan;9(2):103-19.

本文引用的文献

1
Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment.人血清中纤维蛋白原裂解产物的定量测定及其与诊断和治疗的关系
Blood. 1966 Jul;28(1):1-18.
2
Fibrinogen titre, fibrinolysis and platelet stickiness correlated with capillary bleeding or block in the skin.纤维蛋白原滴度、纤维蛋白溶解及血小板黏附性与皮肤毛细血管出血或阻塞相关。
Trans St Johns Hosp Dermatol Soc. 1969;55(2):218-22.
3
Fibrinolytic activity and haemagglutination inhibition immunoassays.纤维蛋白溶解活性和血凝抑制免疫测定
Scand J Haematol. 1970;7(4):261-73. doi: 10.1111/j.1600-0609.1970.tb01897.x.
4
The origin of fibrin breakdown products and the interpretation of their appearance in the circulation.纤维蛋白降解产物的来源及其在循环中出现的解读。
J Clin Pathol. 1972 Mar;25(3):185-90. doi: 10.1136/jcp.25.3.185.
5
The association between cutaneous vasculitis and decreased blood fibrinolytic activity.
Br J Dermatol. 1971 Feb;84(2):99-105. doi: 10.1111/j.1365-2133.1971.tb06850.x.
6
Cutaneous vasculitis: antigen-antibody complexes and prolonged fibrinolysis.皮肤血管炎：抗原抗体复合物与纤溶延长。
Proc R Soc Med. 1972 Mar;65(3):276-8. doi: 10.1177/003591577206500323.
7
The role of immune complexes and complement in tissue injury.免疫复合物和补体在组织损伤中的作用。
J Allergy. 1968 Sep;42(3):113-29. doi: 10.1016/0021-8707(68)90085-3.
8
Coagulation and fibrinolysis in chronic panniculitis.慢性脂膜炎中的凝血与纤溶
Acta Derm Venereol. 1970;50(3):213-7.
9
Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo.
Lancet. 1969 May 3;1(7601):910-4. doi: 10.1016/s0140-6736(69)92545-8.
10
Introduction of intravascular coagulation and focal tissue necrosis in rats by administration of anti-connective tissue antibodies.通过给予抗结缔组织抗体在大鼠体内引发血管内凝血和局部组织坏死。
Am J Pathol. 1968 Nov;53(5):835-50.

皮肤血管炎患者纤溶治疗效果的临床与实验室双盲研究

Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis.

作者信息

Dodman B, Cunliffe W J, Roberts B E, Sibbald R

出版信息

Br Med J. 1973 Apr 14;2(5858):82-4. doi: 10.1136/bmj.2.5858.82.

DOI:10.1136/bmj.2.5858.82
PMID:4573315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1589113/
Abstract

The effects of phenformin and ethyloestrenol and phenformin and stanozolol on the clinical state, plasma fibrinolytic activity, and fibrinogen-fibrin-related antigen (F.R.-antigen) were compared with placebo in 13 patients with cutaneous vasculitis. Eight patients showed considerable clinical improvement when taking phenformin and an anabolic steroid; an impaired fibrinolytic activity before treatment favoured clinical improvement.

摘要

在13例皮肤血管炎患者中，将苯乙双胍与乙基雌烯醇、苯乙双胍与司坦唑醇联用对临床状态、血浆纤溶活性以及纤维蛋白原 - 纤维蛋白相关抗原（F.R. - 抗原）的影响与安慰剂进行了比较。8例患者在服用苯乙双胍和一种合成代谢类固醇时临床症状有显著改善；治疗前纤溶活性受损有利于临床症状改善。