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Synthesis and some pharmacological properties of [Glu(OMe)4]oxytocin and [Mpr1, Glu(OMe)4]oxytocin.

作者信息

Photaki I, Tzougraki C, Kotsira-Engonopoulos C

出版信息

Int J Pept Protein Res. 1979 Apr;13(4):426-33. doi: 10.1111/j.1399-3011.1979.tb01902.x.

DOI:10.1111/j.1399-3011.1979.tb01902.x
PMID:457336
Abstract

[Glu(OMe)4]oxytocin (XVI) and [Mpr1, Glu(OMe)4]oxytocin (XVII) bearing a methyl ester group in place of the carboxamide group in position 4 of oxytocin were synthesized by (3 + 6) segment condensation using the S-trityl group for the protection of the cysteine side chains. Analogue XVI exhibited 10.5 U/mg in vitro uterotonic, and 42 U/mg avian vasodepressor, activity, and analogue XVII 21.4 U/mg and 82 U/mg of the respective activities. Both compounds showed no response in the rat pressor assay.

摘要

相似文献

1
Synthesis and some pharmacological properties of [Glu(OMe)4]oxytocin and [Mpr1, Glu(OMe)4]oxytocin.
Int J Pept Protein Res. 1979 Apr;13(4):426-33. doi: 10.1111/j.1399-3011.1979.tb01902.x.
2
Synthesis and some pharmacological properties (4-beta-(2-thienyl)-L-alanine)oxytocin.（4-β-（2-噻吩基）-L-丙氨酸）催产素的合成及一些药理学性质
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J Med Chem. 1978 Jan;21(1):117-20. doi: 10.1021/jm00199a023.
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Studies on the importance of the asparagine residue in oxytocin. Synthesis and some pharmacological properties of [1-alpha-mercaptoacetic acid, 5-isoasparagine] oxytocin.关于催产素中天冬酰胺残基重要性的研究。[1-α-巯基乙酸，5-异天冬酰胺]催产素的合成及某些药理学性质。
Int J Pept Protein Res. 1980 Mar;15(3):279-84. doi: 10.1111/j.1399-3011.1980.tb02578.x.
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Effect of changing the COOH-terminal amide group present in the hydrophilic cluster of oxytocin to dimethylamide.将催产素亲水性簇中存在的羧基末端酰胺基团改为二甲基酰胺的效果。
J Med Chem. 1980 Jun;23(6):693-5. doi: 10.1021/jm00180a026.
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[4-(0-methyl)-L-threonine] -oxytocin. Synthesis and uterotonic activity.[4-(O-甲基)-L-苏氨酸]-催产素。合成及子宫收缩活性
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Oxytocin analogs with substitutions in postions 3 and 4.在第3和第4位有取代基的催产素类似物。
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Analogues of a potent oxytocin antagonist with truncated C-terminus or shorter amino acid side chain of the basic amino acid at position 8.具有截短的C末端或第8位碱性氨基酸较短氨基酸侧链的强效催产素拮抗剂类似物。
J Pept Sci. 2003 Jun;9(6):393-401. doi: 10.1002/psc.471.

引用本文的文献

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