链霉蛋白酶对胰腺β细胞分泌及形态的影响。
Pronase effect on pancreatic beta cell secretion and morphology.
作者信息
Orci L, Amherdt M, Henquin J C, Lambert A E, Unger R H, Renold A E
出版信息
Science. 1973 May 11;180(4086):647-9. doi: 10.1126/science.180.4086.647.
PMID:4573394
Abstract
Pronase at low concentration (4 micrograms per milliliter) produces a reversible increase of glucose-stimulated insulin release in isolated islets of Langerhans. Pronase also affects the ultrastructure of the beta cells by inducing extensive development of tight junctions as well as the accumulation of secretory product within the extracellular spaces.
摘要
低浓度（每毫升4微克）的链霉蛋白酶可使分离的胰岛中葡萄糖刺激的胰岛素释放出现可逆性增加。链霉蛋白酶还会影响β细胞的超微结构，诱导紧密连接广泛形成以及细胞外间隙中分泌产物的积累。
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