Ryu S, Albert D M
Invest Ophthalmol Vis Sci. 1979 Aug;18(8):831-41.
Sequential histopathological observations were made of the rabbit corneas after an implantation of viable and nonviable tumor cells in the corneal stroma. They showed a nonspecific localized interstitial keratitis accompanied by inflammatory cells and new capillaries. We could not observe any significant clinical or histopathological differences between the corneas containing live or dead tumor implants, or between those with different tumor types (i.e., retinoblastoma and melanoma). Some variation in the severity of the inflammatory response was observed in different animals with the same tumor. In all cases, the extent of the corneal neovascularization correlated with the degree of inflammation. However, in rabbits made immune-deficient by radiation, there was negligible inflammation and vascularization when tumor was implanted.
对兔角膜基质植入活的和非活的肿瘤细胞后的组织病理学变化进行了连续观察。结果显示为非特异性局限性间质性角膜炎，伴有炎症细胞和新生毛细血管。我们未观察到含有活肿瘤植入物或死肿瘤植入物的角膜之间，或不同肿瘤类型（即视网膜母细胞瘤和黑色素瘤）的角膜之间存在任何显著的临床或组织病理学差异。在患有相同肿瘤的不同动物中观察到炎症反应严重程度存在一些差异。在所有病例中，角膜新生血管形成的程度与炎症程度相关。然而，在经辐射导致免疫缺陷的兔中，植入肿瘤时炎症和血管形成可忽略不计。
