Allen W D, Porter P
Immunology. 1973 Feb;24(2):365-74.
The cellular distribution of IgA and secretory component in porcine intestinal mucosa has been studied by immunofluorescence. Secretory component was localized in crypt epithelium of all animals examined. It was also demonstrated in goblet cells on the villi of colostrum-fed neonates and of older animals, both colostrum-deprived and conventionally suckled, and in the crypt epithelial cells of an 80-day-old foetus and of colostrum-deprived new born animals. Sequential biopsy studies on a young fistulated animal demonstrated that the onset of active secretion of intestinal IgA did not occur before the second week of life. The significance of these findings is discussed in relation to the synthesis and transport of IgA.
通过免疫荧光法研究了猪肠黏膜中IgA和分泌成分的细胞分布。分泌成分定位于所有被检查动物的隐窝上皮细胞。在初乳喂养的新生儿以及年龄较大的动物（包括未喂初乳和常规哺乳的动物）绒毛上的杯状细胞中也有发现，在80日龄胎儿和未喂初乳的新生动物的隐窝上皮细胞中也有发现。对一只年轻的造瘘动物进行的连续活检研究表明，肠道IgA的活跃分泌在出生后第二周之前并未开始。结合IgA的合成和运输对这些发现的意义进行了讨论。
