Falk R E, Guttmann R D, Falk J A, Beaudoin J G, Deveber G, Morehouse D D, Wilson D R
Clin Exp Immunol. 1973 May;14(1):47-56.
The cellular response to HL-A antigens has been studied in thirty-one patients who had received a renal allograft from either a cadaveric or living donor, utilizing the leucocyte migration technique. The results indicate that inhibition of migration develops prior to or during the onset of a clinical rejection episode. This inhibition of migration reverts to non-inhibition in autologous serum when the rejection crisis is reversed. Inhibition of migration is still noted in allogeneic serum following this clinical reversal, but after varying time intervals the inhibition reaction also decreases in this serum. The abrogation of inhibition in autologous serum is specific to the HL-A antigens of the donor. These observations suggest that survival of human renal allografts depends on a blocking substance in the serum initially; subsequently, the loss of inhibition of migration with HL-A antigens in both autologous and allogeneic serum suggests an inactivation of specific antigen sensitive cells to the histocompatibility antigens of the donor.
利用白细胞迁移技术，对31例接受尸体或活体供者肾脏同种异体移植的患者的细胞对HL - A抗原的反应进行了研究。结果表明，在临床排斥反应发作之前或发作期间，迁移抑制就已出现。当排斥危机得到缓解时，这种迁移抑制在自体血清中恢复为非抑制状态。临床缓解后，在同种异体血清中仍可观察到迁移抑制，但经过不同的时间间隔后，这种血清中的抑制反应也会降低。自体血清中抑制作用的消除对供者的HL - A抗原具有特异性。这些观察结果表明，人肾同种异体移植的存活最初依赖于血清中的一种阻断物质；随后，自体和同种异体血清中与HL - A抗原相关的迁移抑制作用的丧失表明，特定的抗原敏感细胞对供者的组织相容性抗原失活。
