对患系统性红斑狼疮的同卵双胞胎进行的临床和免疫学研究。
Clinical and immunologic studies in identical twins discordant for systemic lupus erythematosus.
作者信息
Brunner C M, Horwitz D A, Shann M K, Sturgill B A, Davis J S
出版信息
Am J Med. 1973 Aug;55(2):249-54. doi: 10.1016/0002-9343(73)90176-9.
Middle-aged female identical twins, one of whom had systemic lupus erythematosus (SLE), were evaluated for immunologic reactivity to previous antigenic challenges, including primary immunization with a foreign antigen, keyhole limpet hemocyanin (KLH). These two women had lived together for all of their 58 years and neither was receiving anti-inflammatory or immunosuppressive drugs at the time of these studies. Both twins demonstrated comparable 7S and 198 humoral antibody response to KLH, as well as similar viral antibody titers. However, the twin with SLE was anergic to common antigens, streptokinase-streptodornase, Trichophyton and Candida; furthermore delayed hypersensitivity to KLH did not develop after immunization. This observed discrepancy between humoral and cellular immunity in genetically similar subjects may be significant in the pathogenesis of SLE.
一对中年女性同卵双胞胎，其中一人患有系统性红斑狼疮（SLE），对她们针对先前抗原刺激的免疫反应性进行了评估，包括用外来抗原钥孔戚血蓝蛋白（KLH）进行初次免疫。这两名女性在她们58年的人生中一直生活在一起，在进行这些研究时两人均未服用抗炎或免疫抑制药物。双胞胎姐妹对KLH均表现出相当的7S和19S体液抗体反应，以及相似的病毒抗体滴度。然而，患有SLE的双胞胎对常见抗原链激酶-链道酶、毛癣菌和念珠菌无反应；此外，免疫后对KLH的迟发型超敏反应未出现。在基因相似的个体中观察到的体液免疫和细胞免疫之间的这种差异可能在SLE的发病机制中具有重要意义。
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