在对结核菌素纯蛋白衍生物（PPD）过敏的人类受试者中，来自PPD刺激皮肤部位的巨噬细胞的体外吞噬能力增强。
Enhanced in vitro phagocytic power of macrophages from PPD-stimulated skin sites in human subjects hypersensitive to PPD.
作者信息
Magliulo E, De Feo V, Stirpe A, Riva C, Scevola D
出版信息
Clin Exp Immunol. 1973 Jul;14(3):371-6.
Abstract
By a quantitative Rebuck's skin-window technique human macrophages were collected from individuals either unreactive or hypersensitive to PPD, the latter having recovered from tuberculous infection. testing of macrophages with a strain of proved that cells from hypersensitive convalescents were provided with increased pagocytic and bactericidal activities. An even higher degree of macrophage activation was attained when cells from hypersensitive individuals had previously been stimulated with PPD. Changes of macrophage functions such as those mentioned above might well result from the action on macrophages of lympho-kine-like agents released by sensitized lymphocytes coming in contact with PPD.
摘要
通过定量瑞伯克皮肤窗技术，从对结核菌素纯蛋白衍生物（PPD）无反应或过敏的个体中收集人类巨噬细胞，后者已从结核感染中康复。用一种菌株对巨噬细胞进行检测证明，来自过敏康复者的细胞具有增强的吞噬和杀菌活性。当来自过敏个体的细胞先前用PPD刺激时，巨噬细胞的激活程度更高。上述巨噬细胞功能的变化很可能是由于致敏淋巴细胞与PPD接触后释放的类淋巴因子作用于巨噬细胞所致。
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