Henderson D, Hamernik R P, Hynson K
J Acoust Soc Am. 1979 May;65(5):1231-7. doi: 10.1121/1.382790.
Six monaural chinchillas were exposed to a repetitive, reverberant, impulse noise for a total of five days, 8 h per day. The average peak overpressure within the holding cage was 113 dB. The reverberation time (pressure fluctuation envelope within 20 dB of peak) was 160 ms. Auditory thresholds were measured at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after each day's exposure using either the average-evoked response technique or shock avoidance conditioning. After the last exposure, recovery was monitored for five successive days. Final thresholds were obtained starting at 30 days postexposure after which the animals were sacrificed for cochlear histology. The high frequencies (4, 8 kHz) showed a daily median shift of 40 dB and a 27 dB recovery before the following day's exposure. The low frequencies (0.25, 0.5 kHz) were shifted 35 dB after each day's exposure with a 15 dB recovery overnight. Final median audiograms showed little permanent threshold shift. The cochleagrams for two test animals were found to be normal while the remaining four displayed 10%--40% losses in hair cells at specific cochlear sites.
六只单耳龙猫每天暴露于重复性、混响性脉冲噪声8小时,共持续五天。饲养笼内的平均峰值超压为113分贝。混响时间(峰值20分贝内的压力波动包络)为160毫秒。在每天暴露前后,使用平均诱发反应技术或电击回避条件反射,在0.25、0.5、1、2、4和8千赫频率下测量听觉阈值。最后一次暴露后,连续五天监测恢复情况。在暴露后30天开始获得最终阈值,之后处死动物进行耳蜗组织学检查。高频(4、8千赫)显示每日中位数偏移40分贝,在次日暴露前恢复27分贝。低频(0.25、0.5千赫)在每天暴露后偏移35分贝,夜间恢复15分贝。最终中位数听力图显示几乎没有永久性阈值偏移。发现两只受试动物的耳蜗图正常,而其余四只在特定耳蜗部位的毛细胞损失10% - 40%。