突触体γ-氨基丁酸水平的稳定性及其在确定药物体内作用中的应用：惊厥剂 - Suppr

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Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents.

作者信息

Wood J D, Russell M P, Kurylo E, Newstead J D

出版信息

J Neurochem. 1979 Jul;33(1):61-8. doi: 10.1111/j.1471-4159.1979.tb11706.x.

DOI:10.1111/j.1471-4159.1979.tb11706.x

PMID:458472

Abstract

摘要

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Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents.突触体γ-氨基丁酸水平的稳定性及其在确定药物体内作用中的应用：惊厥剂

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Changes in the amino acid content of nerve endings (synaptosomes) induced by drugs that alter the metabolism of glutamate and gamma-aminobutyric acid.改变谷氨酸和γ-氨基丁酸代谢的药物所诱导的神经末梢（突触体）氨基酸含量的变化。

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Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects.药物引起的11个大鼠脑区神经末梢γ-氨基丁酸含量的变化。与药理作用的相关性。

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Effect of drugs on rat brain, cerebrospinal fluid and blood GABA content.药物对大鼠脑、脑脊液及血液中γ-氨基丁酸含量的影响。

J Neurochem. 1979 Jul;33(1):29-33. doi: 10.1111/j.1471-4159.1979.tb11702.x.

The anticonvulsant action of GABA-elevating agents: a re-evaluation.提高γ-氨基丁酸水平药物的抗惊厥作用：重新评估

J Neurochem. 1975 Sep;25(3):277-82. doi: 10.1111/j.1471-4159.1975.tb06966.x.

Biochemical effects in man and rat of three drugs which can increase brain GABA content.三种可增加脑内γ-氨基丁酸（GABA）含量的药物对人和大鼠的生化作用。

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In vivo effects of aminooxyacetic acid and valproic acid on nerve terminal (synaptosomal) GABA levels in discrete brain areas of the rat. Correlation to pharmacological activities.氨基氧乙酸和丙戊酸对大鼠离散脑区神经末梢（突触体）γ-氨基丁酸水平的体内效应。与药理活性的相关性。

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Release of gamma-aminobutyric acid from isolated brain synaptosomes during semicarbazide-induced convulsions.氨基脲诱导惊厥期间，γ-氨基丁酸从离体脑突触体中的释放。

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Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings.药物诱导的癫痫阈值变化与脑及脑神经末梢中γ-氨基丁酸含量之间的关系。

Naunyn Schmiedebergs Arch Pharmacol. 1981 Sep;317(2):131-4. doi: 10.1007/BF00500068.

Effect of repeated convulsive seizures on brain GABA levels.反复惊厥发作对脑内γ-氨基丁酸水平的影响。

Neurochem Res. 1981 Mar;6(3):267-73. doi: 10.1007/BF00964042.

Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.氨基氧乙酸诱导大鼠脑内γ-氨基丁酸（GABA）的蓄积。与GABA受体的相互作用及在各脑区的分布。

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GABAergic modulation of ethanol-induced motor impairment.乙醇诱导的运动障碍的γ-氨基丁酸能调节

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On the existence of two GABA pools associated with newly synthesized GABA and with newly taken up GABA in nerve terminals.关于神经末梢中与新合成的γ-氨基丁酸（GABA）以及新摄取的GABA相关的两个GABA池的存在情况。

Neurochem Res. 1983 May;8(5):563-73. doi: 10.1007/BF00964697.

In vivo effects of anticonvulsant drugs on nerve terminal (synaptosomal) GABA levels in 11 brain regions of the rat.抗惊厥药物对大鼠11个脑区神经末梢（突触体）γ-氨基丁酸水平的体内效应。

J Neural Transm. 1985;63(2):157-67. doi: 10.1007/BF01252615.

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