Yoshida M, Kumakura M, Kaetsu I
J Pharm Sci. 1979 Jul;68(7):860-2. doi: 10.1002/jps.2600680719.
Polymer-containing tablet preparation was studied using radiation-induced polymerization of glass-forming monomers at low temperatures in the presence of dimethylaminoethyl methacrylate-methyl methacrylate copolymer or methyl acrylate-methacrylic acid copolymer. Drug dissolution from tablets was in the pH 3.0-8.0 range. A copolymer contained in the tablets dissolved in the dissolution medium at a specific pH. Drug dissolution from tablets took place rapidly at pH greater than 6.0 in the presence of methyl acrylate-methacrylic acid copolymer and at pH less than 5.0 in the presence of dimethylaminoethyl methacrylate-methyl methacrylate copolymer. The polymers had fibrous or capillary pore structures in contrast to the spherical pore structures formed in the presence of polyethylene glycol 600.
在甲基丙烯酸二甲氨基乙酯-甲基丙烯酸甲酯共聚物或丙烯酸甲酯-甲基丙烯酸共聚物存在下，利用玻璃形成单体在低温下的辐射诱导聚合反应研究了含聚合物片剂的制备。片剂在pH 3.0 - 8.0范围内的药物溶出情况。片剂中含有的共聚物在特定pH值下溶解于溶出介质中。在丙烯酸甲酯-甲基丙烯酸共聚物存在下，片剂在pH大于6.0时药物快速溶出；在甲基丙烯酸二甲氨基乙酯-甲基丙烯酸甲酯共聚物存在下，片剂在pH小于5.0时药物快速溶出。与聚乙二醇600存在下形成的球形孔结构相比，这些聚合物具有纤维状或毛细管孔结构。
