Palermo P J, Tsai P S
J Pharm Sci. 1979 Jul;68(7):878-60. doi: 10.1002/jps.2600680724.
A high-pressure liquid chromatographic procedure is presented for determining saccharin in various formulations. The method is fast, precise, and accurate and is specific for saccharin in the presence of its most likely impurities and degradation products. Reversed-phase chromatography on a micro-C18 column is utilized with an internal standard, and detection is by UV absorption at 280 nm.
本文介绍了一种用于测定各种制剂中糖精的高压液相色谱法。该方法快速、精确且准确，在存在最可能的杂质和降解产物的情况下对糖精具有特异性。使用微C18柱进行反相色谱分析，并采用内标法，通过280nm处的紫外吸收进行检测。
